Ultrasound and pH dually responsive polymer vesicles for anticancer drug delivery.
Ultrasound and pH dually responsive polymer vesicles for anticancer drug delivery.
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DOI：
10.1038/srep02162
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发表时间：
2013
影响因子：
4.6
通讯作者：
Du, Jianzhong
中科院分区：
文献类型：
--
作者：
Chen, Wenqin;Du, Jianzhong
最近，智能聚合物囊泡因其无尽的潜在应用（例如用于治疗退行性疾病的可调递送载体）而引起了越来越多的兴趣。然而，受温度、光、氧化还原等当前刺激形式的限制，刺激响应囊泡从实验室到床旁的进化似乎还很遥远，由于超声联合化疗已广泛应用于肿瘤治疗，且肿瘤组织中pH值相对较低，我们在此设计了一种新的聚合物囊泡，（超声）和化学（pH）刺激，基于PEO-b-P（DEA-stat-TMA）嵌段共聚物，其中PEO是聚的缩写对于甲基丙烯酸2-（二乙基氨基）乙酯，DEA是甲基丙烯酸（2-四氢呋喃氧基）乙酯。这些双重响应囊泡在低于250 μ g/mL时显示无细胞毒性，并且可以包封抗癌药物，当在37 ° C下经受超声辐射或在tris缓冲液中改变pH时，表现出延迟释放曲线和可控释放速率。
Recently, smart polymer vesicles have attracted increasing interest due to their endless potential applications such as tunable delivery vehicles for the treatment of degenerative diseases. However, the evolution of stimuli-responsive vesicles from bench to bedside still seems far away for the limitations of current stimuli forms such as temperature, light, redox, etc. Since ultrasound combined with chemotherapy has been widely used in tumor treatment and the pH in tumor tissues is relatively low, we designed herein a novel polymer vesicle that respond to both physical (ultrasound) and chemical (pH) stimuli based on a PEO-b-P(DEA-stat-TMA) block copolymer, where PEO is short for poly(ethylene oxide), DEA for 2-(diethylamino)ethyl methacrylate and TMA for (2-tetrahydrofuranyloxy)ethyl methacrylate. These dually responsive vesicles show noncytotoxicity below 250 μg/mL and can encapsulate anticancer drugs, exhibiting retarded release profile and controllable release rate when subjected to ultrasound radiation or varying pH in tris buffer at 37°C.
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