In vitro biological effects of magnetic nanoparticles

In vitro biological effects of magnetic nanoparticles
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磁性纳米颗粒的体外生物学效应

DOI:
10.1007/s11434-012-5295-8
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发表时间:
2012-07
影响因子:
--
通讯作者:
Gu Ning
Gu Ning
中科院分区:
--
文献类型:
--
作者:
Li Yan;Chen ZhongWen;Gu Ning

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磁性纳米粒子具有独特的性质,在生物医学领域有着广泛的应用前景。深入研究纳米粒子的生物学效应对许多应用至关重要。到目前为止,许多不同的结果可以在文献中找到关于纳米粒子的生物因子的相互作用。本文综述了这一领域的最新进展,特别侧重于体外MNP-细胞相互作用。讨论了MNP性质对细胞摄取的影响及MNP的细胞毒性评价。还包括一些使用的方法。此外,纳米颗粒-细胞相互作用由纳米颗粒上从生物流体吸收的蛋白质的存在介导。关于纳米颗粒表面(除了纳米颗粒尺寸之外)对蛋白质吸附的影响仍然存在许多问题。我们也回顾了与此相关的论文。
Magnetic nanoparticles (MNPs) have great potential for a wide use in various biomedical applications due to their unusual properties. It is critical for many applications that the biological effects of nanoparticles are studied in depth. To date, many disparate results can be found in the literature regarding nanoparticle-biological factors interactions. This review highlights recent developments in this field with particular focuses on in vitro MNPs-cell interactions. The effect of MNPs properties on cellular uptake and cytotoxicity evaluation of MNPs were discussed. Some employed methods are also included. Moreover, nanoparticle-cell interactions are mediated by the presence of proteins absorbed from biological fluids on the nanoparticle. Many questions remain on the effect of nanoparticle surface (in addition to nanoparticle size) on protein adsorption. We review papers related to this point too.
DOI: 10.1016/s0022-1759(01)00433-1
发表时间: 2001-10-01
影响因子: 2.2
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