Cortico-subcortical neuronal circuitry associated with reconsolidation of human procedural memories.
Cortico-subcortical neuronal circuitry associated with reconsolidation of human procedural memories.
复制标题
与重新整合人类程序记忆有关的皮质增生神经元电路。
DOI：
10.1016/j.cortex.2013.05.013
复制
发表时间：
2014-09
期刊：
影响因子：
--
通讯作者：
Cohen LG
中科院分区：
文献类型：
--
作者：
Censor N;Dayan E;Cohen LG
哺乳动物大脑通过重新整合来修改现有记忆的能力可能对技能的获得至关重要。记忆修饰的神经机制通常在细胞水平上进行研究。然而，令人惊讶的是，涉及现有程序性记忆日常修改的人类大脑系统水平机制在很大程度上仍然未知。在这里，我们研究了功能磁共振成像区域信号活动和区域间的功能连接的受试者中，运动记忆修改的干扰重复经颅磁刺激（rTMS），相对于受试者与完整的记忆修改。因此，记忆修饰受损的受试者在补充运动区（SMA）的活动较低，M1，SMA，小脑前部之间的功能连接较弱，始终参与早期学习，感觉运动纹状体在后期学习阶段活跃。这些发现，确定了这个网络的参与和成功的记忆修改之间的联系，表明记忆再巩固可能代表了早期和晚期程序学习之间的过渡桥梁，潜在的有效技能获取。
The ability of the mammalian brain to modify existing memories through reconsolidation may be crucial for skill acquisition. The neural mechanisms of memory modification have been commonly studied at the cellular level. Yet surprisingly, the human brain systems-level mechanisms involved in day-to-day modification of existing procedural memories remain largely unknown. Here, we studied differences in fMRI regional signal activity and inter-regional functional connectivity in subjects in whom motor memory modification was interfered with by repetitive transcranial magnetic stimulation (rTMS), relative to subjects with intact memory modification. As a consequence, subjects with impaired memory modification had lower activity in the supplementary motor area (SMA) and weaker functional connectivity between M1, SMA, anterior cerebellum consistently engaged in early learning, and sensorimotor striatum active in later learning stages. These findings, identifying a link between engagement of this network and successful memory modification, suggest that memory reconsolidation may represent a transitional bridge between early and late procedural learning, underlying efficient skill acquisition.
登录
查看更多内容
DOI：
10.1523/jneurosci.2184-09.2009
发表时间：
2009-07-15
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Galea JM;Jayaram G;Ajagbe L;Celnik P
通讯作者：
Celnik P
影响因子：
9.2
作者：
Censor, Nitzan;Dimyan, Michael A.;Cohen, Leonardo G.
通讯作者：
Cohen, Leonardo G.
影响因子：
56.9
作者：
Karpicke, Jeffrey D.;Roediger, Henry L., III
通讯作者：
Roediger, Henry L., III
影响因子：
25
作者：
Korman, Maria;Doyon, Julien;Karni, Avi
通讯作者：
Karni, Avi
影响因子：
14.5
作者：
Hummel, F;Celnik, P;Cohen, LG
通讯作者：
Cohen, LG