Prenatal dehydration alters renin-angiotensin system associated with angiotensin-increased blood pressure in young offspring.
Prenatal dehydration alters renin-angiotensin system associated with angiotensin-increased blood pressure in young offspring.
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DOI：
10.1038/hr.2009.155
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发表时间：
2009-12
影响因子：
5.4
通讯作者：
Xu, Zhice
中科院分区：
文献类型：
--
作者：
Guan, Junchang;Mao, Caiping;Xu, Feichao;Geng, Chunsong;Zhu, Liyan;Wang, Aiqing;Xu, Zhice
肾素-血管紧张素系统（RAS）在心血管稳态中具有重要作用。本研究确定了妊娠期缺水对大鼠RAS发育的影响，并检查了青春期后代的血压（BP）。孕鼠在妊娠晚期被剥夺水分3天，我们检查胎儿心脏超微结构，以及心脏血管紧张素（Ang）II受体蛋白和mRNA，肝脏血管紧张素原和血浆Ang II浓度。我们还测试了年轻后代对血管紧张素II的心血管反应。宫内暴露于母体禁水显著降低胎儿体重和心脏重量，并增加胎儿血浆钠和渗透压。胎肝血管紧张素原mRNA、血浆Ang I和Ang II浓度也升高。虽然胎儿AT 1a和AT 1b受体mRNA和AT 1蛋白没有改变，AT 2受体mRNA和蛋白水平在心脏显着增加后，母亲脱水。产前暴露于母体水剥夺对基线BP没有影响，但是，它显着增加血压响应静脉血管紧张素II输注，并降低压力反射敏感性的后代。此外，心脏AT 2受体的mRNA和蛋白质在产前脱水暴露的后代更高。这项研究的结果表明，产前脱水影响RAS的发展与血管紧张素II增加血压在胎儿起源。
The renin–angiotensin system (RAS) has an important role in cardiovascular homeostasis. This study determined the influence of water deprivation during pregnancy on the development of the RAS in rats, and examined blood pressure (BP) in the adolescent offspring. Pregnant rats were water deprived for 3 days at late gestation, and we examined fetal cardiac ultrastructure, as well as heart angiotensin (Ang) II receptor protein and mRNA, liver angiotensinogen and plasma Ang II concentrations. We also tested cardiovascular responses to i.v. Ang II in the young offspring. In utero exposure to maternal water deprivation significantly decreased fetal body and heart weight, and increased fetal plasma sodium and osmolality. Fetal liver angiotensinogen mRNA, plasma Ang I and Ang II concentrations were also increased. Although fetal AT1a and AT1b receptor mRNA and AT1 protein were not changed, AT2 receptor mRNA and protein levels in the heart were significantly increased following maternal dehydration. Prenatal exposure to maternal water deprivation had no effect on baseline BP; however, it significantly increased BP in response to i.v. Ang II infusion, and decreased baroreflex sensitivity in the offspring. In addition, the heart AT2 receptor mRNA and protein were higher in the offspring exposed to prenatal dehydration. The results of this study demonstrate that prenatal dehydration affected the RAS development associated with an Ang II-increased BP in fetal origin.
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影响因子：
--
作者：
DINICOLANTONIO, R;MENDELSOHN, FAO
通讯作者：
MENDELSOHN, FAO
影响因子：
8.3
作者：
Alexander, BT
通讯作者：
Alexander, BT
影响因子：
10.8
作者：
Franco, MDP;Akamine, EH;Nigro, D
通讯作者：
Nigro, D
DOI：
10.1016/j.devbrainres.2004.02.007
发表时间：
2004-05-19
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Hu, F;Morrissey, P;Xu, ZC
通讯作者：
Xu, ZC
影响因子：
5.5
作者：
Edwards, LJ;McMillen, IC
通讯作者：
McMillen, IC