Occupation-Associated Fatal Limbic Encephalitis Caused by Variegated Squirrel Bornavirus 1, Germany, 2013.
Occupation-Associated Fatal Limbic Encephalitis Caused by Variegated Squirrel Bornavirus 1, Germany, 2013.
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DOI：
10.3201/eid2406.172027
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发表时间：
2018-06
影响因子：
11.8
通讯作者：
Beer M
中科院分区：
文献类型：
--
作者：
Tappe D;Schlottau K;Cadar D;Hoffmann B;Balke L;Bewig B;Hoffmann D;Eisermann P;Fickenscher H;Krumbholz A;Laufs H;Huhndorf M;Rosenthal M;Schulz-Schaeffer W;Ismer G;Hotop SK;Brönstrup M;Ott A;Schmidt-Chanasit J;Beer M
这一病例强调了与外来松鼠一起工作的人受到溢出感染的风险。边缘脑炎通常被认为是一种自身免疫介导的疾病。然而，最近在德国北方动物园的一只普雷沃斯特松鼠（Callosciurus prevostii）中检测到人畜共患的杂色松鼠博纳病毒1型后，我们回顾性地调查了在该动物园工作的一名自身抗体阴性动物看护员的死亡病例。该病毒于2015年被发现，是德国东部杂色松鼠（Sciurus variegatoides）饲养者发生致命脑炎的原因。分子检测和免疫组织化学检测到病毒在动物看护者脑组织中的边缘分布。系统发育分析表明，从普雷沃斯特的松鼠溢出感染。通过免疫荧光和新开发的ELISA和免疫印迹法在患者的脑脊液中检测到针对博纳病毒的抗体。在病毒核蛋白上鉴定了推定的抗原表位。其他动物园工作人员没有被感染;但是，建议避免与外来松鼠直接接触，并对松鼠进行筛查。
This case underscores the risk for spillover infections to humans who work with exotic squirrels. Limbic encephalitis is commonly regarded as an autoimmune-mediated disease. However, after the recent detection of zoonotic variegated squirrel bornavirus 1 in a Prevost’s squirrel (Callosciurus prevostii) in a zoo in northern Germany, we retrospectively investigated a fatal case in an autoantibody-seronegative animal caretaker who had worked at that zoo. The virus had been discovered in 2015 as the cause of a cluster of cases of fatal encephalitis among breeders of variegated squirrels (Sciurus variegatoides) in eastern Germany. Molecular assays and immunohistochemistry detected a limbic distribution of the virus in brain tissue of the animal caretaker. Phylogenetic analyses demonstrated a spillover infection from the Prevost’s squirrel. Antibodies against bornaviruses were detected in the patient’s cerebrospinal fluid by immunofluorescence and newly developed ELISAs and immunoblot. The putative antigenic epitope was identified on the viral nucleoprotein. Other zoo workers were not infected; however, avoidance of direct contact with exotic squirrels and screening of squirrels are recommended.
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DOI：
10.12659/ajcr.901391
发表时间：
2017-01-18
期刊：
The American journal of case reports
影响因子：
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作者：
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DOI：
10.1016/s1474-4422(15)00401-9
发表时间：
2016-04
期刊：
The Lancet. Neurology
影响因子：
--
作者：
Graus F;Titulaer MJ;Balu R;Benseler S;Bien CG;Cellucci T;Cortese I;Dale RC;Gelfand JM;Geschwind M;Glaser CA;Honnorat J;Höftberger R;Iizuka T;Irani SR;Lancaster E;Leypoldt F;Prüss H;Rae-Grant A;Reindl M;Rosenfeld MR;Rostásy K;Saiz A;Venkatesan A;Vincent A;Wandinger KP;Waters P;Dalmau J
通讯作者：
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