Wiring patterns from auditory sensory neurons to the escape and song-relay pathways in fruit flies.
Wiring patterns from auditory sensory neurons to the escape and song-relay pathways in fruit flies.
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DOI：
10.1002/cne.24877
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发表时间：
2020-08
期刊：
影响因子：
--
通讯作者：
Kamikouchi A
中科院分区：
文献类型：
--
作者：
Kim H;Horigome M;Ishikawa Y;Li F;Lauritzen JS;Card G;Bock DD;Kamikouchi A
许多动物依靠声音线索来决定下一步采取什么行动。解开听觉神经通路的布线模式是理解这种信息处理的先决条件。在这里，我们重建的第一步听觉神经通路的果蝇大脑，从初级到次级听觉神经元，在透射电子显微镜的分辨率。通过追踪果蝇听觉感觉神经元的两个主要亚群--低频调谐的约翰斯顿氏器（JO）-B神经元和高频调谐的JO-A神经元的轴突，我们观察到JO-B神经元与主要的二级神经元在鸣唱传递和逃逸通路中的广泛联系。相比之下，JO-A神经元与逃逸通路中的神经元紧密相连。我们的研究结果表明，异质性JO神经元群体可以招募到修改逃避行为，而只有特定的JO神经元有助于求爱行为。我们还发现，所有的JO神经元的轴突突触后的网站。果蝇JO神经元输出部位的突触前调制可以影响听觉神经通路的信息加工。使用果蝇大脑的电子显微镜图像的高分辨率数据集，我们追踪了听觉感觉神经元的两个主要亚组，JO-A和JO-B，以及主要的下游神经元，AMMC-B1和GF，分别在歌曲中继和逃逸通路中的轴突。JO-A和JO-B神经元沿着其轴突具有丰富的前突触和后突触。特定类型的JO-A和JO-B神经元进入AMMC-B1和/或GF通路。
Many animals rely on acoustic cues to decide what action to take next. Unraveling the wiring patterns of the auditory neural pathways is prerequisite for understanding such information processing. Here we reconstructed the first step of the auditory neural pathway in the fruit fly brain, from primary to secondary auditory neurons, at the resolution of transmission electron microscopy. By tracing axons of two major subgroups of auditory sensory neurons in fruit flies, low-frequency tuned Johnston’s organ (JO)-B neurons and high-frequency tuned JO-A neurons, we observed extensive connections from JO-B neurons to the main second-order neurons in both the song-relay and escape pathways. In contrast, JO-A neurons connected strongly to a neuron in the escape pathway. Our findings suggest that heterogeneous JO neuronal populations could be recruited to modify escape behavior whereas only specific JO neurons contribute to courtship behavior. We also found that all JO neurons have postsynaptic sites at their axons. Presynaptic modulation at the output sites of JO neurons could affect information processing of the auditory neural pathway in flies. Using a high-resolution dataset of electron microscopy images of a fruit fly brain, we traced the axons of two major subgroups of auditory sensory neurons, JO-A and JO-B, and major downstream neurons, AMMC-B1 and GF, in the song-relay and escape pathways, respectively. JO-A and JO-B neurons have abundant pre- and post-synapses along their axons. Specific types of JO-A and JO-B neurons feed into the AMMC-B1 and/or GF pathways.
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DOI：
10.1002/cne.23966
发表时间：
2016-06-15
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Rybak J;Talarico G;Ruiz S;Arnold C;Cantera R;Hansson BS
通讯作者：
Hansson BS
影响因子：
5.3
作者：
Pezier, Adeline;Jezzini, Sami H.;Blagburn, Jonathan M.
通讯作者：
Blagburn, Jonathan M.
影响因子：
16.2
作者：
Lehnert BP;Baker AE;Gaudry Q;Chiang AS;Wilson RI
通讯作者：
Wilson RI
影响因子：
4.6
作者：
Fukutomi M;Ogawa H
通讯作者：
Ogawa H
影响因子：
3.5
作者：
Ishikawa Y;Okamoto N;Nakamura M;Kim H;Kamikouchi A
通讯作者：
Kamikouchi A