Nonlinear registration of longitudinal images and measurement of change in regions of interest.

Nonlinear registration of longitudinal images and measurement of change in regions of interest.
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DOI:
10.1016/j.media.2011.02.005
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发表时间:
2011-08
影响因子:
10.9
通讯作者:
Dale, Anders M.
Dale, Anders M.
中科院分区:
工程技术1区
文献类型:
--
作者:
Holland, Dominic;Dale, Anders M.

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我们在此描述一种基于连续磁共振成像(MRI)扫描准确量化器官结构变化的方法——Quarc。该程序可用于整体或在感兴趣区域(ROIs)测量变形,包括整个器官的大规模变化以及小尺度结构的细微变化。我们通过模型研究验证了该方法,并使用大脑进行了示例分析。我们将该方法应用于大型的、公开可用的连续脑部扫描的阿尔茨海默病神经影像学倡议(ADNI)数据库,并计算了几个感兴趣区域的科恩d效应量。利用公开可用的衍生数据,我们直接将Quarc的效应量与四种现有的量化大脑结构变化的方法的效应量进行比较。与标准的KN - BSI方法相比,Quarc产生的全脑效应量略有改善,尽管差异不显著,但在所有其他情况下,它产生的效应量明显更大。
We describe here a method, Quarc, for accurately quantifying structural changes in organs, based on serial MRI scans. The procedure can be used to measure deformations globally or in regions of interest (ROIs), including large-scale changes in the whole organ, and subtle changes in small-scale structures. We validate the method with model studies, and provide an illustrative analysis using the brain. We apply the method to the large, publicly available ADNI database of serial brain scans, and calculate Cohen’s d effect sizes for several ROIs. Using publicly available derived-data, we directly compare effect sizes from Quarc with those from four existing methods that quantify cerebral structural change. Quarc produced a slightly improved, though not significantly different, whole brain effect size compared with the standard KN-BSI method, but in all other cases it produced significantly larger effect sizes.
DOI: 10.1006/nimg.1998.0396
发表时间: 1999-02-01
期刊: NEUROIMAGE
影响因子: 5.7
作者:
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发表时间: 2009-12-02
期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
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期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
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通讯作者: Alzheimer's Disease Neuroimaging Initiative
DOI: 10.1259/0007-1285-68-816-1271
发表时间: 1995-12-01
影响因子: 2.6
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通讯作者: Bydder, GM
DOI: 10.1006/nimg.1998.0395
发表时间: 1999-02-01
期刊: NEUROIMAGE
影响因子: 5.7
作者:
Dale, AM;Fischl, B;Sereno, MI
通讯作者: Sereno, MI