Broken or maladaptive? Altered trajectories in neuroinflammation and behavior after early life adversity.
Broken or maladaptive? Altered trajectories in neuroinflammation and behavior after early life adversity.
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DOI：
10.1016/j.dcn.2014.07.001
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发表时间：
2015-02
影响因子：
4.7
通讯作者：
Brenhouse, Heather C.
中科院分区：
文献类型：
--
作者：
Ganguly, Prabarna;Brenhouse, Heather C.
本文综述了早期生活逆境如何改变神经免疫机制。早期生活逆境的神经免疫致敏影响离散生命阶段的电路。神经免疫和神经发育的影响可以影响行为和脆弱性。免疫和大脑发育中的两性二态性产生了早期生活逆境的明显影响。在发育早期遭受逆境和压力会导致一生都容易患精神疾病。越来越多的证据表明，这种脆弱性的机制起源涉及神经回路和神经免疫活动的异常发育。在这里，我们回顾了目前对应激暴露何时以及如何引发与大脑发育相互作用的神经炎症事件的理解。我们首先回顾了早期生活逆境如何与各种精神病理相关联，以及神经炎症如何在这些病理中发挥作用。然后，我们总结了数据和由此产生的假设，描述了早期生活逆境如何特别改变神经免疫发育和精神后果。最后，我们回顾了性别差异是如何在整个生命周期中导致个人主义脆弱性的。我们认为，了解早期发育过程中的压力如何导致神经或神经胶质损伤，以及经验依赖的可塑性，可能无法为个体应对特定性别或特定生命阶段的挑战做好充分准备，是非常重要的。
This paper reviews how early life adversity alters neuroimmune mechanisms. Neuroimmune sensitization from early life adversity impacts circuitry at discrete life stages. Neuroimmune and neurodevelopmental influences can impact behavior and vulnerability. Sexual dimorphism in immune and brain development yield distinct effects of early life adversity. Exposure to adversity and stress early in development yields vulnerability to mental illnesses throughout the lifespan. Growing evidence suggests that this vulnerability has mechanistic origins involving aberrant development of both neurocircuitry and neuro-immune activity. Here we review the current understanding of when and how stress exposure initiates neuroinflammatory events that interact with brain development. We first review how early life adversity has been associated with various psychopathologies, and how neuroinflammation plays a role in these pathologies. We then summarize data and resultant hypotheses describing how early life adversity may particularly alter neuro-immune development with psychiatric consequences. Finally, we review how sex differences contribute to individualistic vulnerabilities across the lifespan. We submit the importance of understanding how stress during early development might cause outright neural or glial damage, as well as experience-dependent plasticity that may insufficiently prepare an individual for sex-specific or life-stage specific challenges.
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影响因子：
3.5
作者：
Bilbo, Staci D.
通讯作者：
Bilbo, Staci D.
影响因子：
25.8
作者：
Coccaro, Emil F.;Lee, Royce;Coussons-Read, Mary
通讯作者：
Coussons-Read, Mary
影响因子：
6.2
作者：
Bilbo, Staci D.;Smith, Susan H.;Schwarz, Jaclyn M.
通讯作者：
Schwarz, Jaclyn M.
影响因子：
3
作者：
Bilbo SD;Schwarz JM
通讯作者：
Schwarz JM
影响因子：
4.3
作者：
Bock J;Rether K;Gröger N;Xie L;Braun K
通讯作者：
Braun K