Perinatal programming of emotional brain circuits: an integrative view from systems to molecules.
Perinatal programming of emotional brain circuits: an integrative view from systems to molecules.
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DOI：
10.3389/fnins.2014.00011
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发表时间：
2014
影响因子：
4.3
通讯作者：
Braun K
中科院分区：
文献类型：
--
作者：
Bock J;Rether K;Gröger N;Xie L;Braun K
环境的影响，如围产期的压力已被证明程序发育中的有机体，以适应大脑和行为功能，以科普日常生活的挑战。现在越来越多的证据表明，早期生活逆境对大脑和行为功能发育的具体和个体影响是不利环境的类型，强度，时间和持续时间的函数，并且早期生活压力（ELS）是发展行为功能障碍和精神障碍的主要风险因素。动物模型的临床和实验研究结果支持这样的假设，即ELS可以在前额叶和边缘脑区域诱发功能性“疤痕”，这些区域对于情绪控制、学习和记忆功能至关重要。另一方面，“压力接种”的概念是从最近的研究中出现的，这些研究揭示了对ELS的积极功能适应，导致在以后的生活中对压力和其他逆境的恢复力。此外，最近的研究表明，早期的生活经历和由此产生的行为后果可以传递给下一代，导致大脑功能和行为的不利或积极适应的跨代循环。在这篇综述中，我们提出了一个统一的观点，压力脆弱性和弹性的遗传易感性和编程敏感性的背景下，经验预期和跨代表观遗传特征。应激反应神经和内分泌系统的适应性成熟需要环境挑战来优化其功能。反复的环境挑战可以在匹配/不匹配假设的框架内看待，结果，精神病理学或弹性，取决于各自的倾向和以后生活的背景。
Environmental influences such as perinatal stress have been shown to program the developing organism to adapt brain and behavioral functions to cope with daily life challenges. Evidence is now accumulating that the specific and individual effects of early life adversity on the functional development of brain and behavior emerge as a function of the type, intensity, timing and the duration of the adverse environment, and that early life stress (ELS) is a major risk factor for developing behavioral dysfunctions and mental disorders. Results from clinical as well as experimental studies in animal models support the hypothesis that ELS can induce functional “scars” in prefrontal and limbic brain areas, regions that are essential for emotional control, learning and memory functions. On the other hand, the concept of “stress inoculation” is emerging from more recent research, which revealed positive functional adaptations in response to ELS resulting in resilience against stress and other adversities later in life. Moreover, recent studies indicate that early life experiences and the resulting behavioral consequences can be transmitted to the next generation, leading to a transgenerational cycle of adverse or positive adaptations of brain function and behavior. In this review we propose a unifying view of stress vulnerability and resilience by connecting genetic predisposition and programming sensitivity to the context of experience-expectancy and transgenerational epigenetic traits. The adaptive maturation of stress responsive neural and endocrine systems requires environmental challenges to optimize their functions. Repeated environmental challenges can be viewed within the framework of the match/mismatch hypothesis, the outcome, psychopathology or resilience, depends on the respective predisposition and on the context later in life.
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影响因子：
10.6
作者：
Bale, Tracy L.;Baram, Tallie Z.;Brown, Alan S.;Goldstein, Jill M.;Insel, Thomas R.;McCarthy, Margaret M.;Nemeroff, Charles B.;Reyes, Teresa M.;Simerly, Richard B.;Susser, Ezra S.;Nestler, Eric J.
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影响因子：
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通讯作者：
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