Effect of OCT B-Scan Density on Sensitivity for Detection of Intraretinal Hyperreflective Foci in Eyes with Age-Related Macular Degeneration.
Effect of OCT B-Scan Density on Sensitivity for Detection of Intraretinal Hyperreflective Foci in Eyes with Age-Related Macular Degeneration.
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DOI：
10.1080/02713683.2022.2081981
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发表时间：
2022-09
影响因子：
2
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中科院分区：
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为了评价降低光学相干断层扫描（OCT）体积中的B扫描密度对检测中度年龄相关性黄斑变性（AMD）患者视网膜内高反射灶（IHRF）的灵敏度的影响，在这项回顾性分析中，共对165只中度AMD和IHRF患者进行了评价。对于每种情况，将Cirrus HD-OCT体积导入到阅读中心3D-OCTOR软件中。根据所有128个B型扫描（间隔47 μm），使用分类量表（分级为1-4、5-9、10- 1 - 4、15-19和>20）评估IHRF病例数。此外，体积中的B扫描密度降低至64次B扫描（间隔94 μm）、43次B扫描（间隔140 μm）和32次B扫描（间隔188 μm）。使用具有任何IHRF的眼睛的数量和眼睛中IHRF的数值类别来比较每个降低的B扫描密度与参考128 B扫描体积的灵敏度。在定性存在或不存在任何IHRF的主要分析中，与128次B扫描参考相比，64次B扫描的灵敏度降至98.2%（p=0.32），43次B扫描的灵敏度降至92.7%（p = 0.001），32次B扫描的灵敏度降至75.2%（p=0.001）。关于每只眼睛的IHRF数量，当B扫描密度降低到43或32次B扫描时（分别为p=0.002和p<0.001），存在显著差异（在量表上选择较低水平）。将B扫描间距从47微米增加到188微米显著降低了准确确定眼睛中是否存在IHRF的能力。B扫描间距增加至140微米与IHRF数量的显著错误分类相关。这些发现可能与利用这些生物标志物进行AMD进展研究的OCT扫描方案设计相关。
To evaluate the impact of reducing the density of B-scans in an optical coherence tomography (OCT) volume on the sensitivity for detecting intraretinal hyperreflective foci (IHRF) in eyes with intermediate age-related macular degeneration (AMD) A total of 165 eyes with intermediate AMD and IHRF were evaluated in this retrospective analysis. For each case, Cirrus HD-OCT volumes were imported into the reading center 3D-OCTOR software. The number of IHRF cases was assessed based on all 128 B-scans (spaced 47 μm apart), using a categorical scale (graded as 1–4, 5–9, 10–14, 15–19, and >20). Additionally, the B-scan densities in the volume were lowered to 64 B-scans (spaced 94 μm apart), 43 B-scans (spaced 140 μm apart), and 32 B-scans (spaced 188 μm apart). The number of eyes with any IHRF and the numerical category of IHRF in the eye were used to compare the sensitivity at each reduced B-scan density against the reference 128 B-scan volume. In the primary analysis for the qualitative presence or absence of any IHRF, the sensitivity decreased to 98.2% (p=0.32) with 64 B-scans, 92.7% (p=0.001) with 43 B-scans, and 75.2% (p=0.001) with 32 B-scans, compared with the 128 B-scan reference. With regard to the number of IHRF per eye, there was a significant difference (with a lower level chosen on the scale) when the B-scan density was reduced to 43 or 32 B-scans (p=0.002 and p<0.001, respectively). Increasing the inter-B-scan spacing from 47 to 188 microns significantly reduced the ability to accurately determine whether IHRF were present in an eye. An increase in inter-B-scan spacing to 140 microns was associated with a significant misclassification of the IHRF quantity. These findings may be relevant in the design of OCT scanning protocols for studies utilizing these biomarkers for AMD progression.
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DOI：
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