Image-based calculation of perfusion and oxyhemoglobin saturation in skeletal muscle during submaximal isometric contractions.
Image-based calculation of perfusion and oxyhemoglobin saturation in skeletal muscle during submaximal isometric contractions.
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DOI：
10.1002/mrm.22475
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发表时间：
2010-09
影响因子：
3.3
通讯作者：
Damon, Bruce M.
中科院分区：
文献类型：
--
作者：
Elder, Christopher P.;Cook, Ryan N.;Chance, Marti A.;Copenhaver, Elizabeth A.;Damon, Bruce M.
血红蛋白的相对氧饱和度（%HbO2）和灌注率（θ今）是重要的生理量，特别是在诸如骨骼肌的器官中，其中氧输送和使用紧密耦合。本研究的目的是证明在等长收缩过程中，基于图像的%HbO2计算和骨骼肌灌注定量。这是通过在动脉闭塞和恒定血容量条件下建立RF可逆失相速率（R2′）和近红外光谱（NIRS）观察到的氧合血红蛋白饱和度（%HbO2）之间的经验关系来实现的。生成校准曲线，并用于根据收缩期间测量的R2′变化计算%HbO2。12名年轻的健康受试者进行了300秒的动脉闭塞，并进行等长收缩的背屈肌在30%的最大收缩120秒。通过动脉自旋标记和肌肉T1的测量，在收缩期间量化肌肉灌注。R2′预测的%HbO2值与NIRS测量值之间的比较显示，两种方法之间无差异（p = 0.760）。在收缩过程中，肌肉灌注达到34.7 mL 100 g −1 min−1。这些测量在测量健康和患病骨骼肌的肌肉耗氧量方面具有未来的前景。
The relative oxygen saturation of hemoglobin (%HbO2) and the rate of perfusion (θ̇) are important physiological quantities, particularly in organs such as skeletal muscle in which oxygen delivery and use are tightly coupled. The purpose of this study was to demonstrate the image-based calculation of %HbO2 and quantification of perfusion in skeletal muscle during isometric contractions. This was accomplished by establishing an empirical relationship between the rate of RF-reversible dephasing (R2′) and near infrared spectroscopy (NIRS)-observed oxyhemoglobin saturation (%HbO2) under conditions of arterial occlusion and constant blood volume. A calibration curve was generated and used to calculate %HbO2 from R2′ changes measured during contraction. Twelve young healthy subjects underwent 300 seconds of arterial occlusion and performed isometric contractions of the dorsiflexors at 30% of maximal contraction for 120s. Muscle perfusion was quantified during contraction by arterial spin labeling and measures of muscle T1. Comparisons between the %HbO2 values predicted from R2′ and that measured by NIRS revealed no differences between methods (p = 0.760). Muscle perfusion reached a value of 34.7 mL 100g−1 min−1 during contraction. These measurements hold future promise in measuring muscle oxygen consumption in healthy and diseased skeletal muscle.
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DOI：
10.1097/00005768-199809000-00006
发表时间：
1998-09-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Price, TB;Kennan, RP;Gore, JC
通讯作者：
Gore, JC
影响因子：
2.9
作者：
Meyer, RA;Prior, BM;Wiseman, RW
通讯作者：
Wiseman, RW
影响因子：
4.8
作者：
GAGNON, DR;ZHANG, TJ;KANNEL, WB
通讯作者：
KANNEL, WB
影响因子：
3.3
作者：
Lebon, V;Brillault-Salvat, C;Carlier, PG
通讯作者：
Carlier, PG
DOI：
10.1002/jmri.1880080516
发表时间：
1998-09-01
期刊：
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING
影响因子：
--
作者：
Donahue, KM;Van Kylen, J;Kissebah, AH
通讯作者：
Kissebah, AH