Racial Differences in Elevated C-Reactive Protein Among US Older Adults.
Racial Differences in Elevated C-Reactive Protein Among US Older Adults.
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DOI：
10.1111/jgs.16187
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发表时间：
2020-02
影响因子：
6.3
通讯作者：
Dupre ME
中科院分区：
文献类型：
--
作者：
Farmer HR;Wray LA;Xian Y;Xu H;Pagidipati N;Peterson ED;Dupre ME
研究美国老年男性和女性c反应蛋白（CRP）升高的种族差异以及导致这些差异的潜在因素。全国代表性队列研究。健康和退休研究，2006年至2014年。居住在美国的非机构非西班牙裔黑人和白人老年人（n = 13 517）。CRP升高（≤3.0 mg/L）和非升高（≤3.0 mg/L）作为主要终点。人口统计背景、社会经济地位、社会心理因素、健康行为和生理健康作为导致CRP升高的种族差异的潜在因素进行了研究。中位CRP水平（四分位数范围）白人为1.67 (3.03)mg/L，黑人为2.62 (4.95)mg/L。随机效应logistic回归模型结果显示，黑人CRP升高的几率明显高于白人（优势比= 2.58；95%可信区间[CI] = 2.20-3.02）。结果还显示，CRP升高的种族差异因性别而有显著差异（预测概率[PP][白人男性]= 0.28 [95% CI = 0.27-0.30]； PP[黑人男性]= 0.38 [95% CI = 0.35 - 0.41]； PP[白人女性]= 0.35 [95% CI = 0.34-0.36]； PP[黑人女性]= 0.49 [95% CI = 0.47-0.52]），并且在风险调整后仍具有显著性。在男性中，CRP升高的种族差异可归因于社会经济因素（12.3%）和行为因素（16.5%）的结合。在女性中，CRP升高的种族差异主要归因于生理因素（40.0%）。在美国老年人群中，黑人比白人更容易出现CRP升高；造成这些差异的因素在男性和女性中有所不同。
To investigate racial differences in elevated C-reactive protein (CRP) and the potential factors contributing to these differences in US older men and women. Nationally representative cohort study. Health and Retirement Study, 2006 to 2014. Noninstitutionalized non-Hispanic black and white older adults living in the United States (n = 13 517). CRP was categorized as elevated (>3.0 mg/L) and nonelevated (≤3.0 mg/L) as the primary outcome. Measures for demographic background, socioeconomic status, psychosocial factors, health behaviors, and physiological health were examined as potential factors contributing to race differences in elevated CRP. Median CRP levels (interquartile range) were 1.67 (3.03) mg/L in whites and 2.62 (4.95) mg/L in blacks. Results from random effects logistic regression models showed that blacks had significantly greater odds of elevated CRP than whites (odds ratio = 2.58; 95% confidence interval [CI] = 2.20–3.02). Results also showed that racial difference in elevated CRP varied significantly by sex (predicted probability [PP] [white men] = 0.28 [95% CI = 0.27–0.30]; PP [black men] = 0.38 [95% CI = 0.35–0.41]; PP [white women] = 0.35 [95% CI = 0.34–0.36]; PP [black women] = 0.49 [95% CI = 0.47–0.52]) and remained significant after risk adjustment. In men, the racial differences in elevated CRP were attributable to a combination of socioeconomic (12.3%) and behavioral (16.5%) factors. In women, the racial differences in elevated CRP were primarily attributable to physiological factors (40.0%). In the US older adult population, blacks were significantly more likely to have elevated CRP than whites; and the factors contributing to these differences varied in men and women.
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