Sericin based nanoformulations: a comprehensive review on molecular mechanisms of interaction with organisms to biological applications.
Sericin based nanoformulations: a comprehensive review on molecular mechanisms of interaction with organisms to biological applications.
复制标题
DOI：
10.1186/s12951-021-00774-y
复制
发表时间：
2021-01-22
影响因子：
10.2
通讯作者：
Patra JK
中科院分区：
文献类型：
--
作者：
Das G;Shin HS;Campos EVR;Fraceto LF;Del Pilar Rodriguez-Torres M;Mariano KCF;de Araujo DR;Fernández-Luqueño F;Grillo R;Patra JK
基于纳米技术的产品的进步引导了人们对低成本、生物相容性和易降解材料的广泛研究。丝胶(Sericin，SER)是从蚕茧(尤其是家蚕等)中提取的一种蛋白质，主要由甘氨酸、丝氨酸、天冬氨酸和苏氨酸等氨基酸组成。丝氨酸是一种具有经济可行性的生物相容材料，由于其潜在的交联反应，易于官能化。此外，SER具有固有的生物学特性，这使得其有可能被用作药物制剂的组成部分，具有多种生物医学应用，如抗肿瘤、抗微生物、抗氧化剂和作为组织修复的支架，以及参与转录因子的调节、减少炎症信号分子、刺激间充质细胞的凋亡、迁移和增殖的分子机制。本文综述了基于SER的纳米药物(纳米粒、胶束、薄膜、水凝胶及其杂化体系)的最新创新及其在非常规治疗中的贡献，并考虑到促进其治疗应用的不同分子机制。
The advances in products based on nanotechnology have directed extensive research on low-cost, biologically compatible, and easily degradable materials. Sericin (SER) is a protein mainly composed of glycine, serine, aspartic acid, and threonine amino acids removed from the silkworm cocoon (particularly Bombyx mori and other species). SER is a biocompatible material with economic viability, which can be easily functionalized due to its potential crosslink reactions. Also, SER has inherent biological properties, which makes possible its use as a component of pharmaceutical formulations with several biomedical applications, such as anti-tumor, antimicrobials, antioxidants and as scaffolds for tissue repair as well as participating in molecular mechanisms attributed to the regulation of transcription factors, reduction of inflammatory signaling molecules, stimulation of apoptosis, migration, and proliferation of mesenchymal cells. In this review, the recent innovations on SER-based nano-medicines (nanoparticles, micelles, films, hydrogels, and their hybrid systems) and their contributions for non-conventional therapies are discussed considering different molecular mechanisms for promoting their therapeutic applications.
登录
查看更多内容
DOI：
10.1016/j.ijbiomac.2018.09.146
发表时间：
2018-12-01
影响因子：
8.2
作者：
Arjama, Mukherjee;Mehnath, Sivaraj;Jeyaraj, Murugaraj
通讯作者：
Jeyaraj, Murugaraj
影响因子：
1.2
作者：
Bhuyan, Devangana;Greene, George Warren;Das, Ratul Kumar
通讯作者：
Das, Ratul Kumar
影响因子：
5.8
作者：
Dutta, Soumita;Chowdhury, Trinath;Ghosh, Ananta Kumar
通讯作者：
Ghosh, Ananta Kumar
影响因子：
2.8
作者：
Aramwit, Pornanong;Kanokpanont, Sorada;Srichana, Teerapol
通讯作者：
Srichana, Teerapol
影响因子：
4.9
作者：
Chirila TV;Suzuki S;McKirdy NC
通讯作者：
McKirdy NC