Single and complex spikes relay distinct frequency-dependent circuit information in the hippocampus
Single and complex spikes relay distinct frequency-dependent circuit information in the hippocampus
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单个和复杂的尖峰在海马体中传递不同的频率相关电路信息
DOI：
10.1101/2022.04.06.487256
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Eric Lowet, Daniel J.
中科院分区：
文献类型：
--
作者：
Eric Lowet, Daniel J.
海马神经元产生单一的尖峰或刻板的尖峰脉冲，称为复合尖峰。虽然单一和复杂的尖峰同时出现在同一个神经元中，但它们对信息处理的贡献仍然不清楚。我们分析了清醒小鼠和行为大鼠海马CA1区神经元，结合细胞膜电压成像与光遗传学和细胞外记录。我们发现，网络驱动的阈下膜节律在θ与伽马频率优选夹带复杂与单个尖峰在个别神经元。光遗传膜扰动揭示了阈下θ和γ功率与复杂与单一尖峰的启动之间的因果关系。此外，单一和复杂的尖峰表现出不同的地方字段属性和频率依赖性编码在空间导航。因此，单个海马神经元不整合θ和γ节律到一个组合的尖峰定时代码，而是在空间认知过程中传输频率特异性信息作为单一与复杂尖峰的不同输出模式。
Hippocampal neurons generate either single spikes or stereotyped bursts of spikes known as complex spikes. Although single and complex spikes co-occur in the same neuron, their contribution to information processing remains unclear. We analyzed hippocampal CA1 neurons in awake mice and in behaving rats, combining cellular membrane voltage imaging with optogenetics and extracellular recordings. We found that network-driven subthreshold membrane rhythms in the theta versus gamma frequencies preferably entrained complex versus single spikes in individual neurons. Optogenetic membrane perturbation revealed a causal link between subthreshold theta and gamma power and the initiation of complex versus single spikes. Further, single and complex spikes exhibited different place field properties and frequency-dependent coding during spatial navigation. Thus, individual hippocampal neurons do not integrate theta and gamma rhythms into a combined spike timing code, but instead, transmit frequency-specific information as distinct output modes of single versus complex spikes during spatial cognition.
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影响因子：
5.8
作者：
Xiao S;Lowet E;Gritton HJ;Fabris P;Wang Y;Sherman J;Mount RA;Tseng HA;Man HY;Straub C;Piatkevich KD;Boyden ES;Mertz J;Han X
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影响因子：
25
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
4.3
作者：
Zeldenrust F;Chameau P;Wadman WJ
通讯作者：
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