The Biological Activities and Therapeutic Potentials of Baicalein Extracted from Oroxylum indicum: A Systematic Review.
The Biological Activities and Therapeutic Potentials of Baicalein Extracted from Oroxylum indicum: A Systematic Review.
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DOI：
10.3390/molecules25235677
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发表时间：
2020-12-02
期刊：
影响因子：
--
通讯作者：
Tan SC
中科院分区：
文献类型：
--
作者：
Nik Salleh NNH;Othman FA;Kamarudin NA;Tan SC
在东南亚，传统医学有着悠久的历史，并在医疗保健系统中发挥着重要作用。自古以来，各种传统药用植物就被用来治疗疾病，这些传统知识中的大部分至今仍被保留下来。木蝴蝶（Oroxylum indicum）是广泛分布于亚洲的药用植物之一。它是一种用途广泛的植物，据报道，该植物的几乎每个部分都具有广泛的药理活性。黄芩的许多重要生物活性都与黄芩中含量最丰富的活性成分黄芩素有关。然而，目前还没有系统的综述来报道和证实从O. indicum来治疗人类疾病。在本综述中，我们旨在系统地介绍基于关键词“木蝴蝶”和“黄芩素”从PubMed、ScienceDirect、Scopus和Google Scholar数据库中检索到的截至2020年3月31日的体内和体外研究。在对标题和摘要进行初步筛选，然后进行全文分析和验证后，本系统性综述纳入了20篇符合所有纳入和排除标准的文章。所检索的资料全面报道了黄芩素的生物活性和治疗潜力。具有抗癌、抗菌、抗高血糖、神经生成、心脏保护、抗脂肪生成、抗炎和伤口愈合作用的印度植物。尽管如此，我们注意到，在人类临床研究中，这种天然活性化合物的功效缺乏证据。总之，这篇系统评价文章提供了新的见解O。从现代科学的角度来看，indicum及其活性成分黄芩素作为一种有前景的补充疗法。我们指出，这种天然产品的潜力，在未来发展成为更认真和明智的循证医学。然而，我们也建议进行更多的临床研究，以确认黄芩素作为治疗药物对患者的有效性和安全性。
In Southeast Asia, traditional medicine has a longestablished history and plays an important role in the health care system. Various traditional medicinal plants have been used to treat diseases since ancient times and much of this traditional knowledge remains preserved today. Oroxylum indicum (beko plant) is one of the medicinal herb plants that is widely distributed throughout Asia. It is a versatile plant and almost every part of the plant is reported to possess a wide range of pharmacological activities. Many of the important bioactivities of this medicinal plant is related to the most abundant bioactive constituent found in this plant—the baicalein. Nonetheless, there is still no systematic review to report and vindicate the biological activities and therapeutic potential of baicalein extracted from O. indicum to treat human diseases. In this review, we aimed to systematically present in vivo and in vitro studies searched from PubMed, ScienceDirect, Scopus and Google Scholar database up to 31 March 2020 based on keywords “Oroxylum indicum” and “baicalein”. After an initial screening of titles and abstracts, followed by a full-text analysis and validation, 20 articles that fulfilled all the inclusion and exclusion criteria were included in this systematic review. The searched data comprehensively reported the biological activities and therapeutic potential of baicalein originating from the O. indicum plant for anti-cancer, antibacterial, anti-hyperglycemia, neurogenesis, cardioprotective, anti-adipogenesis, anti-inflammatory and wound healing effects. Nonetheless, we noticed that there was a scarcity of evidence on the efficacy of this natural active compound in human clinical studies. In conclusion, this systematic review article provides new insight into O. indicum and its active constituent baicalein as a prospective complementary therapy from the perspective of modern and scientific aspect. We indicate the potential of this natural product to be developed into more conscientious and judicious evidencebased medicine in the future. However, we also recommend more clinical research to confirm the efficacy and safety of baicalein as therapeutic medicine for patients.
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影响因子：
2.9
作者：
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通讯作者：
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