Current strategies to improve the bioactivity of PEEK.

Current strategies to improve the bioactivity of PEEK.
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当前提高 PEEK 生物活性的策略

DOI:
10.3390/ijms15045426
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发表时间:
2014-03-28
影响因子:
5.6
通讯作者:
Tang T
Tang T
中科院分区:
生物学2区
文献类型:
--
作者:
Ma R;Tang T

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合成热塑性聚合物聚醚醚酮(PEEK)正在成为临床骨科和脊柱应用的流行成分,但其实际使用存在一些限制。尽管PEEK具有生物相容性、化学稳定性、放射性,并且具有与正常人骨相似的弹性模量,但它具有生物惰性,在植入时无法与相邻骨组织良好整合。最近的努力集中在增加PEEK的生物活性,以改善骨-植入物界面。有两种主要策略可用于克服PEEK的惰性。一种方法是通过单独的表面处理或与表面涂层组合的表面改性来活化PEEK。另一种策略是通过将生物活性材料浸渍到PEEK基体中来制备生物活性PEEK复合材料。研究人员认为,改性生物活性PEEK将有广泛的骨科应用。
The synthetic thermoplastic polymer polyetheretherketone (PEEK) is becoming a popular component of clinical orthopedic and spinal applications, but its practical use suffers from several limitations. Although PEEK is biocompatible, chemically stable, radiolucent and has an elastic modulus similar to that of normal human bone, it is biologically inert, preventing good integration with adjacent bone tissues upon implantation. Recent efforts have focused on increasing the bioactivity of PEEK to improve the bone-implant interface. Two main strategies have been used to overcome the inert character of PEEK. One approach is surface modification to activate PEEK through surface treatment alone or in combination with a surface coating. Another strategy is to prepare bioactive PEEK composites by impregnating bioactive materials into PEEK substrate. Researchers believe that modified bioactive PEEK will have a wide range of orthopedic applications.
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