Quantifying the importance of disease burden on perceived general health and depressive symptoms in patients within the Mayo Clinic Biobank.
Quantifying the importance of disease burden on perceived general health and depressive symptoms in patients within the Mayo Clinic Biobank.
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DOI：
10.1186/s12955-015-0285-6
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发表时间：
2015-07-03
影响因子：
3.6
通讯作者：
Sloan JA
中科院分区：
文献类型：
--
作者：
Ryu E;Takahashi PY;Olson JE;Hathcock MA;Novotny PJ;Pathak J;Bielinski SJ;Cerhan JR;Sloan JA
健康相关生活质量 (HRQOL) 的缺陷可能与较差的患者体验、结果甚至生存有关。虽然有证据表明患有癌症等个体疾病的患者与 HRQOL 缺陷相关的风险因素，但在不关注特定疾病的更一般人群中，这一点还不太确定。这项研究使用了患有多种健康状况的患者来确定对 HRQOL 缺陷影响最大的因素。使用 21,736 名 Mayo Clinic Biobank (MCB) 参与者的数据评估了自我感知的总体健康状况和抑郁症状。每个领域都被分为与健康状况不佳相关的类别：缺陷（一般健康状况较差/一般，PHQ-2 抑郁症状≥3）或非缺陷。使用逻辑回归模型来测试通常收集的人口特征和疾病负担与每个 HRQOL 领域的关联，并根据年龄和性别进行调整。应用梯度增强机 (GBM) 模型来量化贡献者对每个 HRQOL 领域的相对影响。参与者总体健康认知缺陷的患病率为 9.5%，抑郁症状认知缺陷的患病率为 4.6%。对于两组来说，疾病负担对 HRQOL 缺陷的影响最大（一般健康状况占 63%，抑郁症状占 42%）。对于抑郁症状，年龄同样有影响。对于男性来说，一般健康缺陷的患病率随着年龄的增长而略有增加，但对于女性来说，随着年龄的增长，总体健康缺陷的患病率保持稳定。抑郁症状的缺乏与年龄成反比。对于这两个 HRQOL 领域，缺陷风险与较高的疾病负担、较低的教育水平、不饮酒、吸烟和肥胖有关。与没有赤字的受试者相比，有赤字的受试者不太可能报告他们目前正在为报酬而工作；这种关联在男性中比在女性中更强烈。共病健康负担对自我感知总体健康缺陷的影响最大，而人口因素的影响相对较小。对于抑郁症状，年龄和共病健康负担同样重要，随着年龄的增长，抑郁症状的缺陷会减少。为了解释患者报告的指标和比较，必须考虑共病健康负担。
Deficits in health-related quality of life (HRQOL) may be associated with worse patient experiences, outcomes and even survival. While there exists evidence to identify risk factors associated with deficits in HRQOL among patients with individual medical conditions such as cancer, it is less well established in more general populations without attention to specific illnesses. This study used patients with a wide range of medical conditions to identify contributors with the greatest influence on HRQOL deficits. Self-perceived general health and depressive symptoms were assessed using data from 21,736 Mayo Clinic Biobank (MCB) participants. Each domain was dichotomized into categories related to poor health: deficit (poor/fair for general health and ≥3 for PHQ-2 depressive symptoms) or non-deficit. Logistic regression models were used to test the association of commonly collected demographic characteristics and disease burden with each HRQOL domain, adjusting for age and gender. Gradient boosting machine (GBM) models were applied to quantify the relative influence of contributors on each HRQOL domain. The prevalence of participants with a deficit was 9.5 % for perception of general health and 4.6 % for depressive symptoms. For both groups, disease burden had the strongest influence for deficit in HRQOL (63 % for general health and 42 % for depressive symptoms). For depressive symptoms, age was equally influential. The prevalence of a deficit in general health increased slightly with age for males, but remained stable across age for females. Deficit in depressive symptoms was inversely associated with age. For both HRQOL domains, risk of a deficit was associated with higher disease burden, lower levels of education, no alcohol consumption, smoking, and obesity. Subjects with deficits were less likely to report that they were currently working for pay than those without a deficit; this association was stronger among males than females. Comorbid health burden has the strongest influence on deficits in self-perceived general health, while demographic factors show relatively minimal impact. For depressive symptoms, both age and comorbid health burden were equally important, with decreasing deficits in depressive symptoms with increasing age. For interpreting patient-reported metrics and comparison, one must account for comorbid health burden.
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影响因子：
3.7
作者：
Coste J;Quinquis L;D'Almeida S;Audureau E
通讯作者：
Audureau E
影响因子：
7.2
作者：
Bogner, Hillary R.;de Vries, Heather F.;Unuetzer, Juergen
通讯作者：
Unuetzer, Juergen
影响因子：
5
作者：
Idler, EL;Benyamini, Y
通讯作者：
Benyamini, Y
DOI：
10.1038/oby.2003.33
发表时间：
2003-02-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Heo, M;Allison, DB;Fontaine, KR
通讯作者：
Fontaine, KR
影响因子：
18.2
作者：
Hoekstra, Tialda;Jaarsma, Tiny;Lesman-Leegte, Ivonne
通讯作者：
Lesman-Leegte, Ivonne