Serum Copper, Zinc, and Iron Levels in Patients with Alzheimer's Disease: A Meta-Analysis of Case-Control Studies.
Serum Copper, Zinc, and Iron Levels in Patients with Alzheimer's Disease: A Meta-Analysis of Case-Control Studies.
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DOI：
10.3389/fnagi.2017.00300
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发表时间：
2017
影响因子：
4.8
通讯作者：
Zhao P
中科院分区：
文献类型：
--
作者：
Li DD;Zhang W;Wang ZY;Zhao P
背景资料：许多出版物研究了金属离子与阿尔茨海默病（AD）风险之间的关系，但结果不明确。目的：本研究的目的是通过病例对照研究的荟萃分析评估金属（铜/锌/铁）血清水平与AD风险之间的关联。研究方法：我们筛选了Pubmed、Embase、科克伦图书馆、Web of Science和ClinicalTrials. gov电子数据库中1978年以后发表的文献。按照PRISMA（Preferred Reporting Items for Systematic Reviews and Meta-Analyses）指南对407篇文献进行了系统评价，其中44篇文献符合所有纳入标准。使用Review Manager 5.3软件计算每项研究的可用数据。结果如下：与其他荟萃分析的结论一致，我们的结果显示血清铜水平显著高于[MD = 9.27，95%CI（5.02-13.52）; p < 0.0001]，AD患者的血清锌水平显著低于健康对照组[MD =-6.12，95%CI（-9.55，-2.69）; p = 0.0005]。排除两项研究后，AD患者的血清铁水平显著低于健康对照[MD = −13.01，95%CI（−20.75，−5.27）; p = 0.001]。结论：我们的荟萃分析结果为血清金属水平与AD风险之间的关联提供了严格的统计学支持，表明血清铜水平与AD风险之间呈正相关，血清锌/铁水平与AD风险之间呈负相关。
Background: Many publications have investigated the association between metal ions and the risk of Alzheimer's disease (AD), but the results were ambiguous. Aims: The objective of this study was to assess the association between the serum levels of metals (copper/zinc/iron) and the risk of AD via meta-analysis of case-control studies. Methods: We screened literatures published after 1978 in the Pubmed, Embase, Cochrane library, Web of Science and ClinicalTrials.gov. Electronic databases. By using Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, we performed a systematic review of the 407 publications, there are 44 of these publications met all inclusion criteria. The Review Manager 5.3 software was used to calculate available data from each study. Results: Consistent with the conclusions of other meta-analysis, our results demonstrated serum copper levels were significantly higher [MD = 9.27, 95% CI (5.02–13.52); p < 0.0001], and the serum zinc levels were significantly lower in AD patients than in healthy controls [MD = −6.12, 95% CI (−9.55, −2.69); p = 0.0005]. Serum iron levels were significantly lower in AD patients than in healthy controls after excluded two studies [MD = −13.01, 95% CI (−20.75, −5.27); p = 0.001]. Conclusion: The results of our meta-analysis provided rigorous statistical support for the association of the serum levels of metals and the risk of AD, suggesting a positive relationship between the serum copper levels and AD risk, and a negative relationship between the serum zinc/iron levels and AD risk.
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DOI：
10.1039/c6mt00150e
发表时间：
2016-10-01
期刊：
Metallomics : integrated biometal science
影响因子：
--
作者：
Cheignon C;Faller P;Testemale D;Hureau C;Collin F
通讯作者：
Collin F
DOI：
10.1177/1533317512467674
发表时间：
2013-02-01
影响因子：
3.4
作者：
Huang, Ching-Wen;Wang, Shang-Jang;Cheng, Irene H.
通讯作者：
Cheng, Irene H.
影响因子：
3.5
作者：
KAPAKI, E;SEGDITSA, J;PAPAGEORGIOU, C
通讯作者：
PAPAGEORGIOU, C
影响因子：
3.2
作者：
Hidalgo, Juan;Penkowa, Milena;Ortega-Aznar, Arantxa
通讯作者：
Ortega-Aznar, Arantxa
DOI：
10.1177/1533317510382283
发表时间：
2010-11-01
影响因子：
3.4
作者：
Brewer, George J.;Kanzer, Steve H.;Dick, Robert
通讯作者：
Dick, Robert