A new species of Giardia Künstler, 1882 (Sarcomastigophora: Hexamitidae) in hamsters.
A new species of Giardia Künstler, 1882 (Sarcomastigophora: Hexamitidae) in hamsters.
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仓鼠中的贾第鞭毛虫新种，1882 年（肉鞭毛目：Hexamitidae）
DOI：
10.1186/s13071-018-2786-8
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发表时间：
2018-03-20
影响因子：
3.2
通讯作者：
Wen J
中科院分区：
文献类型：
--
作者：
Lyu Z;Shao J;Xue M;Ye Q;Chen B;Qin Y;Wen J
研究背景贾第鞭毛虫是鞭毛原生动物寄生虫，感染人类和世界各地的许多其他脊椎动物。结果本文报道了一新种，薄皮贾第鞭毛虫（Giardiacricetidarum n.）sp.在仓鼠中。滋养体G.骨突;长14 μm（12-18 μm），宽10 μm（8-12 μm），具4对鞭毛。新种的滋养体通常比大多数其他贾第鞭毛虫的滋养体更大更粗壮。在所有已知的贾第鞭毛虫中，其长宽比最低（c.1.40）。G.骨突;卵圆形，平均长11 μm（9-12 μm），宽10 μm（8-10 μm），与其它贾第鞭毛虫的孢囊无明显区别。基于β-贾第丁、小亚基rRNA和延伸因子-1 α位点的分子系统发育分析均表明，G.骨突;在遗传上不同于所有目前公认的贾第虫属。宿主范围调查表明，该新种仅见于仓鼠（Phodopus sungorus，P. campbelli和Mesocricetus auratus），而其它已报道的哺乳动物寄生种（G. muris、鼠尾草G. microti和G.每个病毒感染多个宿主。交叉传播研究进一步证实了G.骨突;因为它只感染仓鼠。在仓鼠肠道中发现大量滋养体（5 × 105 - 5 × 106），很少发现与其他贾第虫属共感染。结论本研究鉴定了一个新的仓鼠贾第鞭毛虫种，与其他三种不同宿主范围的哺乳动物贾第鞭毛虫一起，可以作为研究贾第鞭毛虫宿主寄生策略进化分歧的模式系统。
BackgroundGiardia spp. are flagellated protozoan parasites that infect humans and many other vertebrates worldwide. Currently seven species of Giardia are considered valid.ResultsHere, we report a new species, Giardia cricetidarum n. sp. in hamsters. Trophozoites of G. cricetidarum n. sp. are pear-shaped with four pairs of flagella and measure on average 14 μm (range 12–18 μm) in length and 10 μm (range 8–12 μm) in width. The trophozoites of the new species are generally larger and stouter than those of most of the other Giardia spp. and exhibit the lowest length/width ratio (c.1.40) of all recognized Giardia species. Cysts of G. cricetidarum n. sp. are ovoid and measure on average 11 μm (range 9–12 μm) in length and 10 μm (range 8–10 μm) in width and are indistinguishable from the cysts of other Giardia species. Molecular phylogenetic analyses based on beta-giardin, small subunit rRNA, and elongation factor-1 alpha loci all demonstrated that G. cricetidarum n. sp. is genetically distinct from all currently accepted Giardia spp. Investigation of the host range indicated that the new species was only found in hamsters (including Phodopus sungorus, P. campbelli and Mesocricetus auratus), while all the other described mammal-parasitizing species (G. muris, G. microti and G. intestinalis) each infect multiple hosts. Cross-transmission studies further demonstrated the apparent host specificity of G. cricetidarum n. sp. as it only infected hamsters. Trophozoites were found in high numbers in hamster intestines (5 × 105 – 5 × 106) and was rarely detected co-infecting with other Giardia spp. in the common hamster, suggesting it has some advantages in parasitizing hamsters.ConclusionsThis study has identified a new species of Giardia, which appears to be specific to hamsters, and together with the three other mammal-parasitizing Giardia species with different host ranges, may be able to be used as a model system for the study of evolutionary divergence of host parasitism strategies in Giardia.
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DOI：
10.1016/j.ijppaw.2016.01.002
发表时间：
2016-04
期刊：
International journal for parasitology. Parasites and wildlife
影响因子：
--
作者：
Hillman A;Ash A;Elliot A;Lymbery A;Perez C;Thompson RCA
通讯作者：
Thompson RCA
影响因子：
4
作者：
Lasek-Nesselquist E;Welch DM;Sogin ML
通讯作者：
Sogin ML
影响因子：
1.7
作者：
Sikes RS;Animal Care and Use Committee of the American Society of Mammalogists
通讯作者：
Animal Care and Use Committee of the American Society of Mammalogists
影响因子：
5.8
作者：
Larkin, M. A.;Blackshields, G.;Higgins, D. G.
通讯作者：
Higgins, D. G.
影响因子：
4.4
作者：
Jerlström-Hultqvist J;Franzén O;Ankarklev J;Xu F;Nohýnková E;Andersson JO;Svärd SG;Andersson B
通讯作者：
Andersson B