Is metagenomics resolving identification of functions in microbial communities?
Is metagenomics resolving identification of functions in microbial communities?
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DOI：
10.1111/1751-7915.12077
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发表时间：
2014-01
影响因子：
5.7
通讯作者：
Chistoserdova L
中科院分区：
文献类型：
--
作者：
Chistoserdova L
我们即将迎来全宏基因组鸟枪法测序（称为宏基因组学）的方法广泛使用十周年。这种方法的应用无疑彻底改变了微生物学及相关领域，包括认识到人类微生物组的重要性。因此，宏基因组学已经为微生物群落的复杂性和动态提供了新的视角，微生物群落是地球生物圈的重要组成部分。大量序列数据的积累也导致了专门为数据分析和可视化提供管道的生物信息学工具的开发激增。然而，需要对该领域进行批判性的展望，以了解从以不断增加的速度生成的大量序列数据库中可能会发生什么以及目前已经获得了什么。
We are coming up on the tenth anniversary of the broad use of the method involving whole metagenome shotgun sequencing, referred to as metagenomics. The application of this approach has definitely revolutionized microbiology and the related fields, including the realization of the importance of the human microbiome. As such, metagenomics has already provided a novel outlook on the complexity and dynamics of microbial communities that are an important part of the biosphere of the planet. Accumulation of massive amounts of sequence data also caused a surge in the development of bioinformatics tools specially designed to provide pipelines for data analysis and visualization. However, a critical outlook into the field is required to appreciate what could be and what has currently been gained from the massive sequence databases that are being generated with ever-increasing speed.
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影响因子：
56.9
作者：
Venter, JC;Remington, K;Smith, HO
通讯作者：
Smith, HO
影响因子：
64.8
作者：
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--
影响因子：
56.9
作者：
Swan, Brandon K.;Martinez-Garcia, Manuel;Stepanauskas, Ramunas
通讯作者：
Stepanauskas, Ramunas
影响因子：
56.9
作者：
Béjà, O;Aravind, L;DeLong, EF
通讯作者：
DeLong, EF
影响因子：
56.9
作者：
Wrighton, Kelly C.;Thomas, Brian C.;Banfield, Jillian F.
通讯作者：
Banfield, Jillian F.