An Effective Treatment of Perimenopausal Syndrome by Combining Two Traditional Prescriptions of Chinese Botanical Drugs.
An Effective Treatment of Perimenopausal Syndrome by Combining Two Traditional Prescriptions of Chinese Botanical Drugs.
复制标题
两药合用治疗围绝经期综合症的有效方法
DOI：
10.3389/fphar.2021.744409
复制
发表时间：
2021
影响因子：
5.6
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Lan J;Wu C;Liang W;Shen J;Zhuo Z;Hu L;Ruan L;Zhang P;Ye X;Xu L;Li C;Lin S;Yang C;Wu S;Dong Y;Ren H;Huang H;Gao B;Yao H;Lin T;Chen X;Li C
民族药理学相关性：有两类植物药中药方剂被用于治疗围绝经期综合征（PMS），这是中年女性向绝经过渡期间出现的一种紊乱。一类是用于治疗因衰老和生殖功能下降导致的肾虚（KD）型PMS，另一类是用于治疗与压力和焦虑相关的肝郁气滞（LQS）型PMS。尽管这些方剂经过了时间的检验，但中药治疗PMS的有效性仍需客观验证，相关的分子机制也仍需研究。
材料与方法：通过对围绝经期大鼠施加慢性束缚应激（CRS）建立PMS模型。基于1H NMR血浆代谢组学以及行为和生理指标，评估植物药中药方剂以及两种方剂组合的有效性。为了研究方剂是否含有能够弥补雌激素水平下降（PMS的主要病因）的配体，采用基于配体的饱和转移差（STD）NMR技术来检测汤剂中可能与雌激素受体相互作用的分子。
结果：经典中药方剂的每种处方都适度减轻了疾病模型的代谢组状态。然而，最佳治疗策略是将针对不同病因的两种中药方剂组合使用，将疾病模型的代谢组状态调整到更年轻大鼠的水平。此外，疾病模型代谢组学的这种改善既不是通过上调雌激素水平，也不是通过补充雌激素类化合物实现的。
结论：分别针对两种病因之一的植物药中药方剂治疗PMS能够适度改善这种紊乱。然而，最佳结果是用一种结合了两种传统方剂成分的汤剂同时治疗两种病因。数据还暗示了PMS植物疗法的一种新模式，因为与激素替代疗法的治疗策略不同，所开的汤剂不含调节雌激素受体活性的相互作用化合物。
Ethnopharmacological relevance: Two types of traditional Chinese formulas of botanical drugs are prescribed for treating perimenopausal syndrome (PMS), a disorder in middle-aged women during their transition to menopause. One is for treating PMS as kidney deficiency (KD) due to senescence and declining reproductive functions, and the other is for treating it as liver qi stagnation (LQS) in association with stress and anxiety. Despite the time-tested prescriptions, an objective attestation to the effectiveness of the traditional Chinese treatment of PMS is still to be established and the associated molecular mechanism is still to be investigated. Materials and methods: A model for PMS was generated from perimenopausal rats with chronic restraint stress (CRS). The effectiveness of traditional Chinese formulas of botanical drugs and a combination of two of the formulas was evaluated based on 1H NMR plasma metabolomic, as well as behavioral and physiological, indicators. To investigate whether the formulas contained ligands that could compensate for the declining level of estrogen, the primary cause of PMS, the ligand-based NMR technique of saturation transfer difference (STD) was employed to detect possible interacting molecules to estrogen receptors in the decoction. Results: Each prescription of the classical Chinese formula moderately attenuated the metabolomic state of the disease model. The best treatment strategy however was to combine two traditional Chinese formulas, each for a different etiology, to adjust the metabolomic state of the disease model to that of rats at a much younger age. In addition, this attenuation of the metabolomics of the disease model was by neither upregulating the estrogen level nor supplementing an estrogenic compound. Conclusion: Treatment of PMS with a traditional Chinese formula of botanical drugs targeting one of the two causes separately could ameliorate the disorder moderately. However, the best outcome was to treat the two causes simultaneously with a decoction that combined ingredients from two traditional prescriptions. The data also implicated a new paradigm for phytotherapy of PMS as the prescribed decoctions contained no interacting compound to modulate the activity of estrogen receptors, in contrast to the treatment strategy of hormone replacement therapy.
登录
查看更多内容
影响因子：
14.8
作者：
Bruning, John B.;Parent, Alexander A.;Gil, German;Zhao, Min;Nowak, Jason;Pace, Margaret C.;Smith, Carolyn L.;Afonine, Pavel V.;Adams, Paul D.;Katzenellenbogen, John A.;Nettles, Kendall W.
通讯作者：
Nettles, Kendall W.
将围膜综合征视为肾脏缺乏的代谢组理由。
DOI：
10.1155/2020/8568353
发表时间：
2020
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Chen X;Wu C;Liang W;Shen J;Zhuo Z;Hu L;Ruan L;Zhang P;Xu L;Li C;Lin S;Lan J;Ren H;Yao H;Zhao T;Gao B;Lin T;Huang H;Li C
通讯作者：
Li C
影响因子：
39.3
作者：
Sare GM;Gray LJ;Bath PM
通讯作者：
Bath PM
影响因子：
3.3
作者：
Liang, S.;Wang, T.;Jin, F.
通讯作者：
Jin, F.
影响因子：
2.6
作者：
Cai, Hao-Bin;Wu, Guang-Liang;Wang, Qi
通讯作者：
Wang, Qi