Forced swim-induced musculoskeletal hyperalgesia is mediated by CRF2 receptors but not by TRPV1 receptors.
Forced swim-induced musculoskeletal hyperalgesia is mediated by CRF2 receptors but not by TRPV1 receptors.
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DOI：
10.1016/j.neuropharm.2013.04.016
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发表时间：
2013-09
影响因子：
4.7
通讯作者：
Larson AA
中科院分区：
文献类型：
--
作者：
Abdelhamid RE;Kovacs KJ;Pasley JD;Nunez MG;Larson AA
人类压力引起的肌肉骨骼疼痛的加剧是通过啮齿动物强迫游泳后的肌肉骨骼痛觉过敏来模拟的。我们推测应激敏感性促肾上腺皮质激素释放因子（CRF）受体和瞬时受体香草酸1（TRPV 1）受体负责游泳应激诱导的肌肉骨骼痛觉过敏。我们证实，冷水游泳（26°C）引起了短暂的，吗啡敏感的握力反应下降，反映了小鼠的肌肉骨骼痛觉过敏。用CRF 2受体拮抗剂astressin 2B预处理，而不是CRF 1受体拮抗剂NBI-35965，减弱这种痛觉过敏。用脱敏剂量的树脂毒素（RTX）对TRPV 1受体进行中枢或外周脱敏，均不能预防由冷水游泳引起的肌肉骨骼痛觉过敏。SB-366791，TRPV 1拮抗剂，也未能影响游泳诱导的痛觉过敏。总之，这些数据表明，游泳应激诱导的肌肉骨骼痛觉过敏是介导的，部分，由CRF 2受体，但独立的TRPV 1受体。
The exacerbation of musculoskeletal pain by stress in humans is modeled by the musculoskeletal hyperalgesia in rodents following a forced swim. We hypothesized that stress-sensitive corticotropin releasing factor (CRF) receptors and transient receptor vanilloid 1 (TRPV1) receptors are responsible for the swim stress-induced musculoskeletal hyperalgesia. We confirmed that a cold swim (26°C) caused a transient, morphine-sensitive decrease in grip force responses reflecting musculoskeletal hyperalgesia in mice. Pretreatment with the CRF2 receptor antagonist astressin 2B, but not the CRF1 receptor antagonist NBI-35965, attenuated this hyperalgesia. Desensitizing the TRPV1 receptor centrally or peripherally using desensitizing doses of resiniferatoxin (RTX) failed to prevent the musculoskeletal hyperalgesia produced by cold swim. SB-366791, a TRPV1 antagonist, also failed to influence swim-induced hyperalgesia. Together these data indicate that swim stress-induced musculoskeletal hyperalgesia is mediated, in part, by CRF2 receptors but is independent of the TRPV1 receptor.
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影响因子：
3.7
作者：
Churyukanov, Maxim;Plaghki, Leon;Mouraux, Andre
通讯作者：
Mouraux, Andre
DOI：
10.1016/j.jpain.2011.03.005
发表时间：
2011-09
期刊：
The journal of pain
影响因子：
--
作者：
Bishnoi M;Bosgraaf CA;Premkumar LS
通讯作者：
Premkumar LS
影响因子：
3.6
作者：
GRISEL, JE;FLESHNER, M;MAIER, SF
通讯作者：
MAIER, SF
DOI：
10.1111/j.1474-8673.1988.tb00168.x
发表时间：
1988-03-01
期刊：
JOURNAL OF AUTONOMIC PHARMACOLOGY
影响因子：
--
作者：
HATA, T;KITA, T;KAWABATA, A
通讯作者：
KAWABATA, A
影响因子：
16.2
作者：
Kim, Yong Ho;Back, Seung Keun;Oh, Seog Bae
通讯作者：
Oh, Seog Bae