Impact of PEGylated Liposomal Doxorubicin and Carboplatin Combination on Glioblastoma.
Impact of PEGylated Liposomal Doxorubicin and Carboplatin Combination on Glioblastoma.
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DOI：
10.3390/pharmaceutics14102183
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发表时间：
2022-10-13
期刊：
影响因子：
5.4
通讯作者：
Alavi, Seyed Ebrahim
中科院分区：
文献类型：
--
作者：
Ghaferi, Mohsen;Raza, Aun;Koohi, Maedeh;Zahra, Warda;Akbarzadeh, Azim;Shahmabadi, Hasan Ebrahimi;Alavi, Seyed Ebrahim
胶质母细胞瘤是一种无法治愈的癌症，5年生存率低于5%。化疗是治疗该疾病的一种治疗方法;然而，由于血脑屏障（BBB）的存在，成功的可能性很低。为了克服这个问题，纳米颗粒是有前途的载体，用于穿过血脑屏障并将药物递送到肿瘤。本研究以聚乙二醇（PEG）脂质体纳米粒（PEG-Lip）为载体，对阿霉素（DOX）和卡铂（CB）的体内外抗肿瘤作用进行了评价。结果表明，制备的PEG-Lip-DOX/CB粒径为212 ± 10 nm，可实现药物的可控释放，52 h后药物释放率为56.3%。此外，PEG-Lip-DOX/CB可以显著增加药物对大鼠胶质瘤C6细胞的细胞毒性作用（载药纳米颗粒和DOX + CB的IC 50分别为8.7和12.9 μM）。体内实验结果还表明，与非聚乙二醇化脂质体（Lip）和DOX + CB相比，聚乙二醇化脂质体更有效地增加药物的治疗效果和减少药物的副作用，其中在PEG-Lip-DOX/CB、Lip-DOX/CB和DOX + CB接收组中，荷胶质母细胞瘤大鼠的存活时间分别为39、35和30天。此外，各组的体重减轻分别为8.7%、10.5%和13%。组织病理学研究也证实了毒性评价的结果。总体而言，本研究的结果表明，DOX和CB封装到PEG-Lip中是一种有前途的方法，可以改善DOX和CB在治疗胶质母细胞瘤的治疗效果和药物副作用方面的性质。
Glioblastoma is an incurable cancer with a 5-year survival chance of less than 5%. Chemotherapy is a therapeutic approach to treating the disease; however, due to the presence of the blood–brain barrier (BBB), the probability of success is low. To overcome this issue, nanoparticles are promising carriers for crossing the BBB and delivering drugs to the tumor. In this study, the anticancer efficacy of doxorubicin (DOX) and carboplatin (CB) loaded into polyethylene glycol (PEG)ylated liposome nanoparticles (PEG-Lip) and in treating brain cancer was evaluated in vitro and in vivo. The results demonstrated that PEG-Lip-DOX/CB with a size of 212 ± 10 nm was synthesized that could release the loaded drugs in a controlled manner, from which 56.3% of the loaded drugs were released after 52 h. In addition, PEG-Lip-DOX/CB could significantly increase the cytotoxicity effects of the drugs against rat glioma C6 cells (IC50: 8.7 and 12.9 µM for the drugs-loaded nanoparticles and DOX + CB, respectively). The in vivo results also demonstrated that PEGylated liposomes, compared to non-PEGylated liposomes (Lip) and DOX + CB, were more efficient in increasing the therapeutic effects and decreasing the side effects of the drugs, in which the survival times of the glioblastoma-bearing rats were 39, 35, and 30 days in the PEG-Lip-DOX/CB, Lip-DOX/CB, and DOX + CB receiver groups, respectively. In addition, the weight loss was found to be 8.7, 10.5, and 13%, respectively, in the groups. The results of the toxicity evaluation were also confirmed by histopathological studies. Overall, the results of this study demonstrated that the encapsulation of DOX and CB into PEG-Lip is a promising approach to improving the properties of DOX and CB in terms of their therapeutic effects and drug side effects for the treatment of glioblastoma.
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毒品重新利用的驱虫药：机遇和挑战。
DOI：
10.1016/j.jsps.2021.04.004
发表时间：
2021-05
期刊：
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
影响因子：
--
作者：
Alavi SE;Ebrahimi Shahmabadi H
通讯作者：
Ebrahimi Shahmabadi H
影响因子：
3.9
作者：
Jiao, Yan;Li, Dajing;Liu, Chunquan;Chang, Ying;Song, Jiangfeng;Xiao, Yadong
通讯作者：
Xiao, Yadong
影响因子：
3.1
作者：
Esfahani, Maedeh Koohi Moftakhari;Alavi, Seyed Ebrahim;Shahmabadi, Hasan Ebrahimi
通讯作者：
Shahmabadi, Hasan Ebrahimi
影响因子：
2.5
作者：
Halas-Wisniewska, Marta;Izdebska, Magdalena;Grzanka, Alina
通讯作者：
Grzanka, Alina
影响因子：
3.8
作者：
Alavi, Seyed Ebrahim;Raza, Aun;Shahmabadi, Hasan Ebrahimi
通讯作者：
Shahmabadi, Hasan Ebrahimi