Microreplication of laser-fabricated surface and three-dimensional structures

Microreplication of laser-fabricated surface and three-dimensional structures
复制标题

激光制造表面和三维结构的微复制

DOI:
10.1088/2040-8978/12/12/124009
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发表时间:
2010
期刊:
影响因子:
2.1
通讯作者:
B. N. Chichkov
B. N. Chichkov
中科院分区:
物理与天体物理4区
文献类型:
--
作者:
A. Koroleva;S. Schlie;E. Fadeeva;S. Gittard;P. Miller;A. Ovsianikov;J. Koch;R. Narayan;B. N. Chichkov

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制造限定的表面形貌和三维结构对于各种应用(例如在光子学和生物医学中)是具有挑战性的过程。基于激光的技术为生产这种结构提供了一种有前途的方法。飞秒激光烧蚀和双光子聚合用于微结构化的优点是众所周知的。然而,这些方法不能适用于所有材料,并且受到其高成本和长生产时间的限制。在这项研究中,生物医学应用的间接快速成型,激光制造的二维和三维结构的成型微复制检查。我们证明,通过这种方法,任何激光生成的表面形貌以及三维结构可以在各种材料中复制,而不会失去原来的几何形状。复制成多个副本能够快速和完美地再现原始微结构,用于细胞表面相互作用的研究。与非结构化材料相比,我们观察到微结构对成纤维细胞的形态和定位有很大的影响,而神经母细胞瘤细胞没有受到负面影响。
The fabrication of defined surface topographies and three-dimensional structures is a challenging process for various applications, eg in photonics and biomedicine. Laser-based technologies provide a promising approach for the production of such structures. The advantages of femtosecond laser ablation and two-photon polymerization for microstructuring are well known. However, these methods cannot be applied to all materials and are limited by their high cost and long production time. In this study, biomedical applications of an indirect rapid prototyping, molding microreplication of laser-fabricated two-and three-dimensional structures are examined. We demonstrate that by this method any laser-generated surface topography as well as three-dimensional structures can be replicated in various materials without losing the original geometry. The replication into multiple copies enables fast and perfect reproducibility of original microstructures for investigations of cell–surface interactions. Compared to unstructured materials, we observe that microstructures have strong influence on morphology and localization of fibroblasts, whereas neuroblastoma cells are not negatively affected.
先进生物陶瓷的激光加工
DOI: --
发表时间: 2005
期刊:
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发表时间: 2005-08-01
期刊: BIOMATERIALS
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DOI: --
发表时间: 2009
期刊:
影响因子: --
作者:
É. Fadeeva;S. Schlie;J. Koch;B. Chichkov;A. Vorobyev;C. Guo
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飞秒激光制造的尖峰结构用于选择性控制细胞行为
DOI: 10.1177/0885328209345553
发表时间: 2010
影响因子: 2.9
作者:
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通讯作者: B. Chichkov