Epigenome-wide association study identifies novel genes associated with ischemic stroke.

Epigenome-wide association study identifies novel genes associated with ischemic stroke.
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全表观基因组关联研究发现与缺血性卒中相关的新基因。

DOI:
10.1186/s13148-023-01520-x
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发表时间:
2023-06-27
影响因子:
5.7
通讯作者:
--
中科院分区:
医学1区
文献类型:
--
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DNA methylation has previously been associated with ischemic stroke, but the specific genes and their functional roles in ischemic stroke remain to be determined. Here we aimed to identify differentially methylated genes that play a functional role in ischemic stroke in a Chinese population. Genome-wide DNA methylation assessed with the Illumina Methylation EPIC Array in a discovery sample including 80 Chinese adults (40 cases vs. 40 controls) found that patients with ischemic stroke were characterized by increased DNA methylation at six CpG loci (individually located at TRIM6, FLRT2, SOX1, SOX17, AGBL4, and FAM84A, respectively) and decreased DNA methylation at one additional locus (located at TLN2). Targeted bisulfite sequencing confirmed six of these differentially methylated probes in an independent Chinese population (853 cases vs. 918 controls), and one probe (located at TRIM6) was further verified in an external European cohort (207 cases vs. 83 controls). Experimental manipulation of DNA methylation in engineered human umbilical vein endothelial cells indicated that the identified differentially methylated probes located at TRIM6, TLN2, and FLRT2 genes may play a role in endothelial cell adhesion and atherosclerosis. Altered DNA methylation of the TRIM6, TLN2, and FLRT2 genes may play a functional role in ischemic stroke in Chinese populations. The online version contains supplementary material available at 10.1186/s13148-023-01520-x.
DOI: 10.1038/s41586-022-05165-3
发表时间: 2022-11
期刊: NATURE
影响因子: 64.8
作者:
Mishra, Aniket;Malik, Rainer;Hachiya, Tsuyoshi;Jurgenson, Tuuli;Namba, Shinichi;Posner, Daniel C.;Kamanu, Frederick K.;Koido, Masaru;Le Grand, Quentin;Shi, Mingyang;He, Yunye;Georgakis, Marios K.;Caro, Ilana;Krebs, Kristi;Liaw, Yi-Ching;Vaura, Felix C.;Lin, Kuang;Winsvold, Bendik Slagsvold;Srinivasasainagendra, Vinodh;Parodi, Livia;Bae, Hee-Joon;Chauhan, Ganesh;Chong, Michael R.;Tomppo, Liisa;Akinyemi, Rufus;Roshchupkin, Gennady V.;Habib, Naomi;Jee, Yon Ho;Thomassen, Jesper Qvist;Abedi, Vida;Carcel-Marquez, Jara;Nygaard, Marianne;Leonard, Hampton L.;Yang, Chaojie;Yonova-Doing, Ekaterina;Knol, Maria J.;Lewis, Adam J.;Judy, Renae L.;Ago, Tetsuro;Amouyel, Philippe;Armstrong, Nicole D.;Bakker, Mark K.;Bartz, Traci M.;Bennett, David A.;Bis, Joshua C.;Bordes, Constance;Borte, Sigrid;Cain, Anael;Ridker, Paul M.;Cho, Kelly;Chen, Zhengming;Cruchaga, Carlos;Cole, John W.;de Jager, Phil L.;de Cid, Rafael;Endres, Matthias;Ferreira, Leslie E.;Geerlings, Mirjam I.;Gasca, Natalie C.;Gudnason, Vilmundur;Hata, Jun;He, Jing;Heath, Alicia K.;Ho, Yuk-Lam;Havulinna, Aki S.;Hopewell, Jemma C.;Hyacinth, Hyacinth I.;Inouye, Michael;Jacob, Mina A.;Jeon, Christina E.;Jern, Christina;Kamouchi, Masahiro;Keene, Keith L.;Kitazono, Takanari;Kittner, Steven J.;Konuma, Takahiro;Kumar, Amit;Lacaze, Paul;Launer, Lenore J.;Lee, Keon-Joo;Lepik, Kaido;Li, Jiang;Li, Liming;Manichaikul, Ani;Markus, Hugh S.;Marston, Nicholas A.;Meitinger, Thomas;Mitchell, Braxton D.;Montellano, Felipe A.;Morisaki, Takayuki;Mosley, Thomas H.;Nalls, Mike A.;Nordestgaard, Borge G.;O'Donnell, Martin J.;Okada, Yukinori;Onland-Moret, N. Charlotte;Ovbiagele, Bruce;Peters, Annette;Psaty, Bruce M.;Rich, Stephen S.;Rosand, Jonathan;Sabatine, Marc S.;Sacco, Ralph L.;Saleheen, Danish;Sandset, Else Charlotte;Salomaa, Veikko;Sargurupremraj, Muralidharan;Sasaki, Makoto;Satizabal, Claudia L.;Schmidt, Carsten O.;Shimizu, Atsushi;Smith, Nicholas L.;Sloane, Kelly L.;Sutoh, Yoichi;Sun, Yan V.;Tanno, Kozo;Tiedt, Steffen;Tatlisumak, Turgut;Torres-Aguila, Nuria P.;Tiwari, Hemant K.;Tregouet, David-Alexandre;Trompet, Stella;Tuladhar, Anil Man;Tybjaerg-Hansen, Anne;van Vugt, Marion;Vibo, Riina;Verma, Shefali S.;Wiggins, Kerri L.;Wennberg, Patrik;Woo, Daniel;Wilson, Peter W. F.;Xu, Huichun;Yang, Qiong;Yoon, Kyungheon;Millwood, Iona Y.;Gieger, Christian;Ninomiya, Toshiharu;Grabe, Hans J.;Jukema, J. Wouter;Rissanen, Ina L.;Strbian, Daniel;Kim, Young Jin;Chen, Pei-Hsin;Mayerhofer, Ernst;Howson, Joanna M. M.;Irvin, Marguerite R.;Adams, Hieab;Wassertheil-Smoller, Sylvia;Christensen, Kaare;Ikram, Mohammad A.;Rundek, Tatjana;Worrall, Bradford B.;Lathrop, G. Mark;Riaz, Moeen;Simonsick, Eleanor M.;Korv, Janika;Franca, Paulo H. C.;Zand, Ramin;Prasad, Kameshwar;Frikke-Schmidt, Ruth;de Leeuw, Frank-Erik;Liman, Thomas;Haeusler, Karl Georg;Ruigrok, Ynte M.;Heuschmann, Peter Ulrich;Longstreth, W. T.;Jung, Keum Ji;Bastarache, Lisa;Pare, Guillaume;Damrauer, Scott M.;Chasman, Daniel I.;Rotter, Jerome I.;Anderson, Christopher D.;Zwart, John-Anker;Niiranen, Teemu J.;Fornage, Myriam;Liaw, Yung-Po;Seshadri, Sudha;Fernandez-Cadenas, Israel;Walters, Robin G.;Ruff, Christian T.;Owolabi, Mayowa O.;Huffman, Jennifer E.;Milani, Lili;Kamatani, Yoichiro;Dichgans, Martin;Debette, Stephanie;Lee, Jin-Moo;Cheng, Yu-Ching;Meschia, James F.;Chen, Wei Min;Sale, Michele M.;Zonderman, Alan B.;Evans, Michele K.;Wilson, James G.;Correa, Adolfo;Traylor, Matthew;Lewis, Cathryn M.;Reiner, Alexander;Haessler, Jeffrey;Langefeld, Carl D.;Gottesman, Rebecca F.;Yaffe, Kristine;Liu, Yong Mei;Kooperberg, Charles;Lange, Leslie A.;Furie, Karen L.;Arnett, Donna K.;Benavente, Oscar R.;Grewal, Raji P.;Peddareddygari, Leema Reddy;Hveem, Kristian;Lindstrom, Sara;Wang, Lu;Smith, Erin N.;Gordon, William;Vlieg, Astrid van Hylckama;de Andrade, Mariza;Brody, Jennifer A.;Pattee, Jack W.;Brumpton, Ben M.;Suchon, Pierre;Chen, Ming-Huei;Frazer, Kelly A.;Turman, Constance;Germain, Marine;MacDonald, James;Braekkan, Sigrid K.;Armasu, Sebastian M.;Pankratz, Nathan;Jackson, Rebecca D.;Nielsen, Jonas B.;Giulianin, Franco;Puurunen, Marja K.;Ibrahim, Manal;Heckbert, Susan R.;Bammler, Theo K.;McCauley, Bryan M.;Taylor, Kent D.;Pankow, James S.;Reiner, Alexander P.;Gabrielsen, Maiken E.;Deleuze, Jean-Francois;O'Donnell, Chris J.;Kim, Jihye;McKnight, Barbara;Kraft, Peter;Hansen, John-Bjarne;Rosendaal, Frits R.;Heit, John A.;Tang, Weihong;Morange, Pierre-Emmanuel;Johnson, Andrew D.;Kabrhel, Christopher;van Dijk, Ewoud J.;Koudstaal, Peter J.;Luijckx, Gert-Jan;Nederkoorn, Paul J.;van Oostenbrugge, Robert J.;Visser, Marieke C.;Wermer, Marieke J. H.;Kappelle, L. Jaap;Esko, Tonu;Metspalu, Andres;Magi, Reedik;Nelis, Mari;Levi, Christopher R.;Maguire, Jane;Jimenez-Conde, Jordi;Sharma, Pankaj;Sudlow, Cathie L. M.;Rannikmae, Kristiina;Schmidt, Reinhold;Slowik, Agnieszka;Pera, Joanna;Thijs, Vincent N. S.;Lindgren, Arne G.;Ilinca, Andreea;Melander, Olle;Engstrom, Gunnar;Rexrode, Kathryn M.;Rothwell, Peter M.;Stanne, Tara M.;Johnson, Julie A.;Danesh, John;Butterworth, Adam S.;Heitsch, Laura;Boncoraglio, Giorgio B.;Kubo, Michiaki;Pezzini, Alessandro;Rolfs, Arndt;Giese, Anne-Katrin;Weir, David;Ross, Owen A.;Lemmons, Robin;Soderholm, Martin;Cushman, Mary;Jood, Katarina;McDonough, Caitrin W.;Bell, Steven;Linkohr, Birgit;Lee, Tsong-Hai;Putaala, Jukka;Lopez, Oscar L.;Carty, Cara L.;Jian, Xueqiu;Schminke, Ulf;Cullell, Natalia;Delgado, Pilar;Ibanez, Laura;Krupinski, Jerzy;Lioutas, Vasileios;Matsuda, Koichi;Montaner, Joan;Muino, Elena;Roquer, Jaume;Sarnowski, Chloe;Sattar, Naveed;Sibolt, Gerli;Teumer, Alexander;Rutten-Jacobs, Loes;Kanai, Masahiro;Gretarsdottir, Solveig;Rost, Natalia S.;Yusuf, Salim;Almgren, Peter;Ay, Hakan;Bevan, Steve;Brown, Robert D., Jr.;Carrera, Caty;Buring, Julie E.;Chen, Wei-Min;Cotlarciuc, Ioana;de Bakker, Paul I. W.;DeStefano, Anita L.;den Hoed, Marcel;Duan, Qing;Engelter, Stefan T.;Falcone, Guido J.;Gustafsson, Stefan;Hassan, Ahamad;Holliday, Elizabeth G.;Howard, George;Hsu, Fang-Chi;Ingelsson, Erik;Harris, Tamara B.;Kissela, Brett M.;Kleindorfer, Dawn O.;Langenberg, Claudia;Leys, Didier;Lin, Wei-Yu;Lorentzen, Erik;Magnusson, Patrik K.;McArdle, Patrick F.;Pulit, Sara L.;Rice, Kenneth;Sakaue, Saori;Sapkota, Bishwa R.;Tanislav, Christian;Thorleifsson, Gudmar;Thorsteinsdottir, Unnur;Tzourio, Christophe;van Duijn, Cornelia M.;Walters, Matthew;Wareham, Nicholas J.;Amin, Najaf;Aparicio, Hugo J.;Attia, John;Beiser, Alexa S.;Berr, Claudine;Bustamante, Mariana;Caso, Valeria;Choi, Seung Hoan;Chowhan, Ayesha;Dartigues, Jean-Francois;Delavaran, Hossein;Dorr, Marcus;Ford, Ian;Gurpreet, Wander S.;Hamsten, Anders;Hozawa, Atsushi;Ingelsson, Martin;Iwasaki, Motoki;Kaffashian, Sara;Kalra, Lalit;Kjartansson, Olafur;Kloss, Manja;Labovitz, Daniel L.;Laurie, Cathy C.;Li, Linxin;Lind, Lars;Lindgren, Cecilia M.;Makoto, Hirata;Minegishi, Naoko;Morris, Andrew P.;Mueller-Nurasyid, Martina;Norrving, Bo;Ogishima, Soichi;Parati, Eugenio A.;Pedersen, Nancy L.;Perola, Markus;Jousilahti, Pekka;Pileggi, Silvana;Rabionet, Raquel;Riba-Llena, Iolanda;Ribases, Marta;Romero, Jose R.;Rudd, Anthony G.;Sarin, Antti-Pekka;Sarju, Ralhan;Satoh, Mamoru;Sawada, Norie;Sigurdsson, Asgeir;Smith, Albert;Stine, O. Colin;Stott, David J.;Strauch, Konstantin;Takai, Takako;Tanaka, Hideo;Touze, Emmanuel;Tsugane, Shoichiro;Uitterlinden, Andre G.;Valdimarsson, Einar M.;van der Lee, Sven J.;Wakai, Kenji;Williams, Stephen R.;Wolfe, Charles D. A.;Wong, Quenna;Yamaji, Taiki;Sanghera, Dharambir K.;Stefansson, Kari;Martinez-Majander, Nicolas;Sobue, Kenji;Soriano-Tarraga, Carolina;Volzke, Henry;Akpa, Onoja;Sarfo, Fred S.;Akpalu, Albert;Obiako, Reginald;Wahab, Kolawole;Osaigbovo, Godwin;Owolabi, Lukman;Komolafe, Morenikeji;Jenkins, Carolyn;Arulogun, Oyedunni;Ogbole, Godwin;Adeoye, Abiodun M.;Akinyemi, Joshua;Agunloye, Atinuke;Fakunle, Adekunle G.;Uvere, Ezinne;Olalere, Abimbola;Adebajo, Olayinka J.;Chen, Junshi;Clarke, Robert;Collins, Rory;Guo, Yu;Wang, Chen;Lv, Jun;Peto, Richard;Chen, Yiping;Fairhurst-Hunter, Zammy;Hill, Michael;Pozarickij, Alfred;Schmidt, Dan;Stevens, Becky;Turnbull, Iain;Yu, Canqing;Nagai, Akiko;Murakami, Yoishinori;Shiroma, Eric J.;Sigurdsson, Sigurdur;Ghanbari, Mohsen;Boerwinkle, Eric;Fongang, Bernard;Wang, Ruiqi;Ikram, Mohammad K.;Volker, Uwe;de Laat, Karlijn F.;van Norden, Anouk G. W.;de Kort, Paul L.;Vermeer, Sarah E.;Brouwers, Paul J. A. M.;Gons, Rob A. R.;den Heijer, Tom;van Dijk, Gert W.;van Rooij, Frank G. W.;Aamodt, Anne H.;Skogholt, Anne H.;Willer, Cristen J.;Heuch, Ingrid;Hagen, Knut;Fritsche, Lars G.;Pedersen, Linda M.;Ellekjaer, Hanne;Zhou, Wei;Martinsen, Amy E.;Kristoffersen, Espen S.;Thomas, Laurent F.;Kleinschnitz, Christoph;Frantz, Stefan;Ungethum, Kathrin;Gallego-Fabrega, Cristina;Lledos, Miquel;Llucia-Carol, Laia;Sobrino, Tomas;Campos, Francisco;Castillo, Jose;Freijo, Marimar;Arenillas, Juan Francisco;Obach, Victor;Alvarez-Sabin, Jose;Molina, Carlos A.;Ribo, Marc;Munoz-Narbona, Lucia;Lopez-Cancio, Elena;Millan, Monica;Diaz-Navarro, Rosa;Vives-Bauza, Cristofol;Serrano-Heras, Gemma;Segura, Tomas;Dhar, Rajat;Delgado-Mederos, Raquel;Prats-Sanchez, Luis;Camps-Renom, Pol;Blay, Natalia;Sumoy, Lauro;Marti-Fabregas, Joan;Schnohr, Peter;Jensen, Gorm B.;Benn, Marianne;Afzal, Shoaib;Kamstrup, Pia R.;van Setten, Jessica;van der Laan, Sander W.;Vonk, Jet M. J.;Kim, Bong-Jo;Curtze, Sami;Tiainen, Marjaana;Kinnunen, Janne;Menon, Vilas;Sung, Yun Ju;Yang, Chengran;Saillour-Glenisson, Florence;Gravel, Simon
通讯作者: Gravel, Simon
DOI: 10.1038/nri2413
发表时间: 2008-11
期刊: Nature reviews. Immunology
影响因子: --
作者:
Ozato K;Shin DM;Chang TH;Morse HC 3rd
通讯作者: Morse HC 3rd
DOI: 10.1001/jamaneurol.2013.5026
发表时间: 2014-02
期刊: JAMA NEUROLOGY
影响因子: 29
作者:
Courties, Gabriel;Moskowitz, Michael A.;Nahrendorf, Matthias
通讯作者: Nahrendorf, Matthias
DOI: 10.1038/s41588-018-0058-3
发表时间: 2018-04
期刊: Nature genetics
影响因子: 30.8
作者:
Malik R;Chauhan G;Traylor M;Sargurupremraj M;Okada Y;Mishra A;Rutten-Jacobs L;Giese AK;van der Laan SW;Gretarsdottir S;Anderson CD;Chong M;Adams HHH;Ago T;Almgren P;Amouyel P;Ay H;Bartz TM;Benavente OR;Bevan S;Boncoraglio GB;Brown RD Jr;Butterworth AS;Carrera C;Carty CL;Chasman DI;Chen WM;Cole JW;Correa A;Cotlarciuc I;Cruchaga C;Danesh J;de Bakker PIW;DeStefano AL;den Hoed M;Duan Q;Engelter ST;Falcone GJ;Gottesman RF;Grewal RP;Gudnason V;Gustafsson S;Haessler J;Harris TB;Hassan A;Havulinna AS;Heckbert SR;Holliday EG;Howard G;Hsu FC;Hyacinth HI;Ikram MA;Ingelsson E;Irvin MR;Jian X;Jiménez-Conde J;Johnson JA;Jukema JW;Kanai M;Keene KL;Kissela BM;Kleindorfer DO;Kooperberg C;Kubo M;Lange LA;Langefeld CD;Langenberg C;Launer LJ;Lee JM;Lemmens R;Leys D;Lewis CM;Lin WY;Lindgren AG;Lorentzen E;Magnusson PK;Maguire J;Manichaikul A;McArdle PF;Meschia JF;Mitchell BD;Mosley TH;Nalls MA;Ninomiya T;O'Donnell MJ;Psaty BM;Pulit SL;Rannikmäe K;Reiner AP;Rexrode KM;Rice K;Rich SS;Ridker PM;Rost NS;Rothwell PM;Rotter JI;Rundek T;Sacco RL;Sakaue S;Sale MM;Salomaa V;Sapkota BR;Schmidt R;Schmidt CO;Schminke U;Sharma P;Slowik A;Sudlow CLM;Tanislav C;Tatlisumak T;Taylor KD;Thijs VNS;Thorleifsson G;Thorsteinsdottir U;Tiedt S;Trompet S;Tzourio C;van Duijn CM;Walters M;Wareham NJ;Wassertheil-Smoller S;Wilson JG;Wiggins KL;Yang Q;Yusuf S;AFGen Consortium;Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium;International Genomics of Blood Pressure (iGEN-BP) Consortium;INVENT Consortium;STARNET;Bis JC;Pastinen T;Ruusalepp A;Schadt EE;Koplev S;Björkegren JLM;Codoni V;Civelek M;Smith NL;Trégouët DA;Christophersen IE;Roselli C;Lubitz SA;Ellinor PT;Tai ES;Kooner JS;Kato N;He J;van der Harst P;Elliott P;Chambers JC;Takeuchi F;Johnson AD;BioBank Japan Cooperative Hospital Group;COMPASS Consortium;EPIC-CVD Consortium;EPIC-InterAct Consortium;International Stroke Genetics Consortium (ISGC);METASTROKE Consortium;Neurology Working Group of the CHARGE Consortium;NINDS Stroke Genetics Network (SiGN);UK Young Lacunar DNA Study;MEGASTROKE Consortium;Sanghera DK;Melander O;Jern C;Strbian D;Fernandez-Cadenas I;Longstreth WT Jr;Rolfs A;Hata J;Woo D;Rosand J;Pare G;Hopewell JC;Saleheen D;Stefansson K;Worrall BB;Kittner SJ;Seshadri S;Fornage M;Markus HS;Howson JMM;Kamatani Y;Debette S;Dichgans M
通讯作者: Dichgans M
DOI: 10.1161/strokeaha.115.009044
发表时间: 2015-08-01
期刊: STROKE
影响因子: 8.3
作者:
Carty, Cara L.;Keene, Keith L.;Fornage, Myriam
通讯作者: Fornage, Myriam