Exploiting amoeboid and non-vertebrate animal model systems to study the virulence of human pathogenic fungi.
Exploiting amoeboid and non-vertebrate animal model systems to study the virulence of human pathogenic fungi.
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DOI：
10.1371/journal.ppat.0030101
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发表时间：
2007-07-27
期刊：
影响因子：
6.7
通讯作者：
Ausubel FM
中科院分区：
文献类型：
--
作者：
Mylonakis E;Casadevall A;Ausubel FM
最近，用昆虫、原生动物、线虫和黏菌进行的实验已经成为宿主-真菌相互作用研究的前沿。在哺乳动物中致病性所需的许多毒力因子在与非脊椎动物宿主的相互作用过程中对真菌的生存也很重要，这表明真菌的毒力可能已经进化并被维持，作为对阿米巴原虫和线虫以及其他以微生物为食的小型非脊椎动物的环境捕食的对策。宿主先天免疫应答在许多门中也是广泛保守的。因此，无脊椎动物模型宿主和病原真菌之间的相互作用的研究提供了深入了解病原体毒力和宿主免疫力的机制，并补充了哺乳动物模型的使用，使整个动物高通量感染测定。这篇综述旨在帮助研究人员在确定合适的无脊椎动物系统的真菌发病机制的特定方面的研究。
Experiments with insects, protozoa, nematodes, and slime molds have recently come to the forefront in the study of host–fungal interactions. Many of the virulence factors required for pathogenicity in mammals are also important for fungal survival during interactions with non-vertebrate hosts, suggesting that fungal virulence may have evolved, and been maintained, as a countermeasure to environmental predation by amoebae and nematodes and other small non-vertebrates that feed on microorganisms. Host innate immune responses are also broadly conserved across many phyla. The study of the interaction between invertebrate model hosts and pathogenic fungi therefore provides insights into the mechanisms underlying pathogen virulence and host immunity, and complements the use of mammalian models by enabling whole-animal high throughput infection assays. This review aims to assist researchers in identifying appropriate invertebrate systems for the study of particular aspects of fungal pathogenesis.
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影响因子：
2.1
作者：
Laws, TR;Smith, SA;Titball, RW
通讯作者：
Titball, RW
影响因子：
3.1
作者：
KWONCHUNG, KJ;EDMAN, JC;WICKES, BL
通讯作者：
WICKES, BL
影响因子：
4.4
作者：
Bellocchio, S;Montagnoli, C;Romani, L
通讯作者：
Romani, L
DOI：
10.1073/pnas.261573998
发表时间：
2001-12-18
影响因子：
11.1
作者：
Irving, P;Troxler, L;Hetru, C
通讯作者：
Hetru, C
基因组分析表明，铜绿假单胞菌的毒力是组合。
影响因子：
12.3
作者：
Lee DG;Urbach JM;Wu G;Liberati NT;Feinbaum RL;Miyata S;Diggins LT;He J;Saucier M;Déziel E;Friedman L;Li L;Grills G;Montgomery K;Kucherlapati R;Rahme LG;Ausubel FM
通讯作者：
Ausubel FM