In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson's disease using neuromelanin-sensitive MRI: Replication in two cohorts.
In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson's disease using neuromelanin-sensitive MRI: Replication in two cohorts.
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DOI：
10.1371/journal.pone.0282684
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发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
帕金森病患者在黑质致密部和蓝斑处会出现含黑色素的神经元缺失。很少有研究同时使用磁共振成像（MRI）评估帕金森病患者黑质致密部和蓝斑的病理情况。基于显式磁化传递对比的对黑质致密部和蓝斑体积进行的神经黑色素敏感MRI测量在对照组中已显示出较高的扫描 - 再扫描重复性，但没有研究使用相同方法在多个队列中重复检测到帕金森病相关的黑质致密部和蓝斑体积减少。从埃默里运动障碍诊所招募了两个独立的帕金森病患者和对照组队列，并在两台不同的MRI扫描仪上进行扫描。在队列1中，使用带有磁化传递准备脉冲的2D梯度回波序列，通过西门子Trio 3T扫描仪获取了19名对照组和22名帕金森病患者的成像数据。队列2包括33名对照组和39名帕金森病患者，他们使用类似的成像协议在西门子Prisma 3T扫描仪上进行扫描。在两个队列中都对蓝斑和黑质致密部体积进行了分割。与两个队列中的对照组相比，帕金森病组的黑质致密部体积（队列1：p = 0.0148；队列2：p = 0.0011）和蓝斑体积（队列1：p = 0.0412；队列2：p = 0.0056）均显著减少。这种成像方法有力地检测到帕金森病对这些结构的影响，表明它是神经退行性神经黑色素缺失的一个有前景的标志物。
Patients with Parkinson’s disease undergo a loss of melanized neurons in substantia nigra pars compacta and locus coeruleus. Very few studies have assessed substantia nigra pars compacta and locus coeruleus pathology in Parkinson’s disease simultaneously with magnetic resonance imaging (MRI). Neuromelanin-sensitive MRI measures of substantia nigra pars compacta and locus coeruleus volume based on explicit magnetization transfer contrast have been shown to have high scan-rescan reproducibility in controls, but no study has replicated detection of Parkinson’s disease-associated volume loss in substantia nigra pars compacta and locus coeruleus in multiple cohorts with the same methodology. Two separate cohorts of Parkinson’s disease patients and controls were recruited from the Emory Movement Disorders Clinic and scanned on two different MRI scanners. In cohort 1, imaging data from 19 controls and 22 Parkinson’s disease patients were acquired with a Siemens Trio 3 Tesla scanner using a 2D gradient echo sequence with magnetization transfer preparation pulse. Cohort 2 consisted of 33 controls and 39 Parkinson’s disease patients who were scanned on a Siemens Prisma 3 Tesla scanner with a similar imaging protocol. Locus coeruleus and substantia nigra pars compacta volumes were segmented in both cohorts. Substantia nigra pars compacta volume (Cohort 1: p = 0.0148; Cohort 2: p = 0.0011) and locus coeruleus volume (Cohort 1: p = 0.0412; Cohort 2: p = 0.0056) were significantly reduced in the Parkinson’s disease group as compared to controls in both cohorts. This imaging approach robustly detects Parkinson’s disease effects on these structures, indicating that it is a promising marker for neurodegenerative neuromelanin loss.
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影响因子：
4.3
作者：
Langley, Jason;Hwang, Kristy S.;Hu, Xiaoping P.;Huddleston, Daniel E.
通讯作者：
Huddleston, Daniel E.
DOI：
10.1093/brain/awab191
发表时间：
2021-11-29
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Biondetti E;Santin MD;Valabrègue R;Mangone G;Gaurav R;Pyatigorskaya N;Hutchison M;Yahia-Cherif L;Villain N;Habert MO;Arnulf I;Leu-Semenescu S;Dodet P;Vila M;Corvol JC;Vidailhet M;Lehéricy S
通讯作者：
Lehéricy S
影响因子：
2.8
作者：
Kitao, Shinichiro;Matsusue, Eiji;Ogawa, Toshihide
通讯作者：
Ogawa, Toshihide
影响因子：
16.6
作者：
Carballo-Carbajal, Iria;Laguna, Ariadna;Vila, Miquel
通讯作者：
Vila, Miquel
影响因子：
4.2
作者：
Langley, Jason;Hussain, Sana;Hu, Xiaoping
通讯作者：
Hu, Xiaoping