The prevalence of Helicobacter pylori infection in inflammatory bowel disease in China: A case-control study.
The prevalence of Helicobacter pylori infection in inflammatory bowel disease in China: A case-control study.
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中国炎症性肠病患者幽门螺杆菌感染的患病率：一项病例对照研究
DOI：
10.1371/journal.pone.0248427
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Lu H
中科院分区：
文献类型：
--
作者：
Ding ZH;Xu XP;Wang TR;Liang X;Ran ZH;Lu H
幽门螺杆菌（H.在中国，尽管炎症性肠病（IBD）的发病率有所增加，但幽门螺杆菌（pylori）感染仍然很高。我们的目的是调查H。幽门螺杆菌和炎症性肠病。住院IBD患者，包括克罗恩病（CD）和溃疡性结肠炎（UC），已检测H。pylori抗体。对照组为年龄、性别匹配的健康体检者，均为H. pylori抗体试验以1：2的方式（IBD患者：对照）。记录IBD病史。所有患者均按Montreal分类进行分型。采用马约临床评分和Harvey-Bradshaw严重程度指数评价其疾病活动性。患者和对照组中H.排除既往接受过幽门螺杆菌根除治疗者。IBD患者260例，其中CD患者213例，UC患者47例，对照组520例。H. IBD患者幽门螺杆菌感染（9.6%，25/260）和IBD新诊断患者（12.1%，8/66），以及CD患者（8.9%，19/213）包括CD新诊断患者（10.6%，5/47）和UC患者（12.8%，6/47）显著低于对照组（29.8%，155/520）（p = 2.796*10 - 10，0.007，5.723*10 - 9，0.016，0.014），而UC新诊断患者与对照组之间无统计学差异，以及不同疾病类型、疾病活动度和治疗史的IBD患者。H. pylori感染与IBD，尤其是CD呈负相关。
Helicobacter pylori (H. pylori) infection remains high in China though the incidence of inflammatory bowel disease (IBD) has increased. Our aim was to investigate the relationship between the prevalence of H. pylori and inflammatory bowel disease. Hospitalized IBD patients including Crohn’s disease (CD) and ulcerative colitis (UC) who had tested H. pylori antibody were enrolled. Controls were chose from age- and sex- matched healthy physical examination people who had H. pylori antibody test in a 1:2 fashion (IBD patients:controls). IBD medical history was recorded. All patients were typed by the Montreal classification. Mayo Clinic score and the Harvey-Bradshaw Severity Index were used to evaluate their disease activity. Patients and controls that had H. pylori eradication therapy before were excluded. Two hundred and sixty IBD patients including 213 CD patients and 47 UC patients, and 520 controls were involved in this study. The prevalence of H. pylori infection in IBD patients (9.6%, 25/260) and IBD newly diagnosed patients (12.1%, 8/66), as well as CD patients (8.9%, 19/213) including CD newly diagnosed patients (10.6%, 5/47) and UC patients (12.8%, 6/47) was significantly lower than controls (29.8%, 155/520) (p = 2.796*10−10, 0.007, 5.723*10−9, 0.016, 0.014), while there was no statistically difference between UC newly diagnosed patients and the controls, and IBD patients with different disease type, disease activity and treatment history. H. pylori infection had a negative association with IBD, especially CD.
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影响因子：
24.5
作者：
Luther J;Owyang SY;Takeuchi T;Cole TS;Zhang M;Liu M;Erb-Downward J;Rubenstein JH;Chen CC;Pierzchala AV;Paul JA;Kao JY
通讯作者：
Kao JY
影响因子：
24.5
作者：
Satsangi, J.;Silverberg, M. S.;Colombel, J-F
通讯作者：
Colombel, J-F
影响因子：
4.6
作者：
Frost, Fabian;Kacprowski, Tim;Lerch, Markus M.
通讯作者：
Lerch, Markus M.
影响因子：
4.9
作者：
Higgins, Peter D. R.;Johnson, Laura A.;Luther, Jay;Zhang, Min;Sauder, Kay L.;Blanco, Luz P.;Kao, John Y.
通讯作者：
Kao, John Y.
影响因子：
29.4
作者：
Kaplan, Gilaad G.;Ng, Siew C.
通讯作者：
Ng, Siew C.