The evolution of heterogeneities altered by mutational robustness, gene expression noise and bottlenecks in gene regulatory networks.
The evolution of heterogeneities altered by mutational robustness, gene expression noise and bottlenecks in gene regulatory networks.
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突变鲁棒性、基因表达噪音和基因调控网络的瓶颈改变了异质性的进化。
DOI：
10.1371/journal.pone.0116167
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Zhang Z
群体内异质性在自然群体和细胞群体中很常见，并且对其进化具有深远的影响。例如，肿瘤内异质性在大多数肿瘤类型中普遍存在，并可能导致肿瘤治疗失败。然而，异质性的进化过程在基因型和表型水平上仍然缺乏表征。在这里，我们研究基因调控网络（GRN）的群体内异质性的演变，特别是突变稳健性和基因表达噪声作为异质性发展的贡献者。通过计算机模拟，发现这些因素对GRN的影响在一定条件下可以促进表型异质性。我们还研究了种群瓶颈对 GRN 进化的影响。当 GRN 群体通过这样的瓶颈时，突变稳健性和群体适应性都没有观察到显着改变。然而有趣的是，我们确实检测到潜在“生成”基因数量显着增加，当受到突变打击刺激时，这些基因可以显着诱导种群适应性。
Intra-population heterogeneity is commonly observed in natural and cellular populations and has profound influence on their evolution. For example, intra-tumor heterogeneity is prevalent in most tumor types and can result in the failure of tumor therapy. However, the evolutionary process of heterogeneity remains poorly characterized at both genotypic and phenotypic level. Here we study the evolution of intra-population heterogeneities of gene regulatory networks (GRN), in particular mutational robustness and gene expression noise as contributors to the development of heterogeneities. By in silico simulations, it was found that the impact of these factors on GRN can, under certain conditions, promote phenotypic heterogeneity. We also studied the effect of population bottlenecks on the evolution of GRN. When the GRN population passes through such bottlenecks, neither mutational robustness nor population fitness was observed to be substantially altered. Interestingly, however, we did detect a significant increase in the number of potential “generator” genes which can substantially induce population fitness, when stimulated by mutational hits.
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影响因子：
9.8
作者：
Kaufmann BB;Yang Q;Mettetal JT;van Oudenaarden A
通讯作者：
van Oudenaarden A
影响因子：
16
作者：
de Krom, M;van de Corput, M;Strouboulis, J
通讯作者：
Strouboulis, J
DOI：
10.1111/j.1749-6632.2009.04880.x
发表时间：
2009-01-01
期刊：
YEAR IN EVOLUTIONARY BIOLOGY 2009
影响因子：
--
作者：
Attolini, Camille Stephan-Otto;Michor, Franziska
通讯作者：
Michor, Franziska
影响因子：
3.3
作者：
Wagner, A
通讯作者：
Wagner, A
影响因子：
56.9
作者：
Lynch, M;Conery, JS
通讯作者：
Conery, JS