Lexical-semantic search related to side of onset and putamen volume in Parkinson's disease.
Lexical-semantic search related to side of onset and putamen volume in Parkinson's disease.
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DOI:
10.1016/j.bandl.2020.104841
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发表时间:
2020-10
影响因子:
2.5
通讯作者:
Huang X
中科院分区:
文献类型:
--
作者:
Wagner D;Eslinger PJ;Sterling NW;Du G;Lee EY;Styner M;Lewis MM;Huang X
Parkinson’s disease (PD) is characterized by dopaminergic cell loss and reduced striatal volume. Prior studies have demonstrated striatal involvement in access to lexical-semantic knowledge and damage to this structure may be evident in the lexical properties of responses. Semantic fluency task responses from early stage, non-demented PD participants with right (PD-R) or left (PD-L) lateralizing symptoms were compared to matched controls on lexical properties (word frequency, age of acquisition) and correlated with striatal volumes segmented from T1-weighted brain MR images. PD-R participants produced semantic fluency responses of a lower age of acquisition than PD-L and control participants (p < 0.05). PD-R age of acquisition responses correlated positively with putamen volume (p< 0.05), while age of acquisition of responses correlated negatively with caudate volume in controls (p< 0.05). Findings provide evidence for a role of the striatum in lexical-semantic access and qualitative changes in lexical access in select PD patients.
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2.5
作者:
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通讯作者:
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DOI:
10.1017/s135561770397010x
发表时间:
2003-11-01
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10.1076/jcen.20.3.391.810
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1998-06-01
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