Serum Levels of Inflammatory Proteins Are Associated With Peripheral Neuropathy in a Cross-Sectional Type-1 Diabetes Cohort.
Serum Levels of Inflammatory Proteins Are Associated With Peripheral Neuropathy in a Cross-Sectional Type-1 Diabetes Cohort.
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炎性蛋白的血清水平与横截面1型糖尿病队列中的周围神经病有关。
DOI：
10.3389/fimmu.2021.654233
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发表时间：
2021
影响因子：
7.3
通讯作者：
She JX
中科院分区：
文献类型：
--
作者：
Purohit S;Tran PMH;Tran LKH;Satter KB;He M;Zhi W;Bai S;Hopkins D;Gardiner M;Wakade C;Bryant J;Bernard R;Morgan J;Bode B;Reed JC;She JX
慢性低度炎症参与1型糖尿病（T1D）及其并发症的发病机制。在这个横断面研究设计中，我们调查了694例1型糖尿病患者血清可溶性细胞因子受体水平与周围神经病变之间的关系。从患者病历中获取性别、年龄、血压、吸烟、饮酒、糖化血红蛋白（HbA1c）和血脂、DPN（外周和自主神经）、视网膜病变和肾病的存在。采用多重免疫分析法测定可溶性细胞因子受体、全身和血管炎症标志物。DPN患者血清水平升高，与性别、年龄和糖尿病病程无关。15/22蛋白的粗比值比与DPN的存在显著相关。在调整混杂变量、HbA1C、高血压和血脂异常后，sTNFRI （1.72, p=0.00001）、sTNFRII （1.45, p=0.0027）、sIL2Rα (1.40, p=0.0023)、IGFBP6 （1.51, p=0.0032）和CRP （1.47, p=0.0046）的优势比（OR）保持不变。进一步，我们发现DPN的风险与血清sTNFRI （OR=11.2, p<10）、sIL2Rα (8.69, p<10-15)、sNTFRII （4.8, p<10-8）和MMP2 （4.5, p<10-5）水平升高相关。我们使用脊回归将血清浓度合并成一个综合评分，将DPN患者分为低、中、高危组。我们的研究结果显示了DPN患者炎症通路的激活，这可能是识别T1D患者进行抗炎治疗干预的潜在临床工具。
Chronic low-grade inflammation is involved in the pathogenesis of type-1 diabetes (T1D) and its complications. In this cross-section study design, we investigated association between serum levels of soluble cytokine receptors with presence of peripheral neuropathy in 694 type-1 diabetes patients. Sex, age, blood pressure, smoking, alcohol intake, HbA1c and lipid profile, presence of DPN (peripheral and autonomic), retinopathy and nephropathy was obtained from patient’s chart. Measurement of soluble cytokine receptors, markers of systemic and vascular inflammation was done using multiplex immunoassays. Serum levels were elevated in in DPN patients, independent of gender, age and duration of diabetes. Crude odds ratios were significantly associated with presence of DPN for 15/22 proteins. The Odds ratio (OR) remained unchanged for sTNFRI (1.72, p=0.00001), sTNFRII (1.45, p=0.0027), sIL2Rα (1.40, p=0.0023), IGFBP6 (1.51, p=0.0032) and CRP (1.47, p=0.0046) after adjusting for confounding variables, HbA1C, hypertension and dyslipidemia. Further we showed risk of DPN is associated with increase in serum levels of sTNFRI (OR=11.2, p<10), sIL2Rα (8.69, p<10-15), sNTFRII (4.8, p<10-8) and MMP2 (4.5, p<10-5). We combined the serum concentration using ridge regression, into a composite score, which can stratify the DPN patients into low, medium and high-risk groups. Our results here show activation of inflammatory pathway in DPN patients, and could be a potential clinical tool to identify T1D patients for therapeutic intervention of anti-inflammatory therapies.
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影响因子：
5.2
作者：
Burrack AL;Martinov T;Fife BT
通讯作者：
Fife BT
1型和2型糖尿病青年糖尿病周围神经病的患病率和危险因素：青年研究中寻找糖尿病。
影响因子：
16.2
作者：
Jaiswal M;Divers J;Dabelea D;Isom S;Bell RA;Martin CL;Pettitt DJ;Saydah S;Pihoker C;Standiford DA;Dolan LM;Marcovina S;Linder B;Liese AD;Pop-Busui R;Feldman EL
通讯作者：
Feldman EL
DOI：
10.1155/edr.2003.65
发表时间：
2003-04
期刊：
Experimental diabesity research
影响因子：
--
作者：
Satoh J;Yagihashi S;Toyota T
通讯作者：
Toyota T
DOI：
10.1016/j.ecl.2010.05.009
发表时间：
2010-09-01
影响因子：
4.5
作者：
Melendez-Ramirez, L. Yvonne;Richards, Robert J.;Cefalu, William T.
通讯作者：
Cefalu, William T.
影响因子：
16.2
作者：
Herman, WH;Kennedy, L
通讯作者：
Kennedy, L