Specialized motor-driven dusp1 expression in the song systems of multiple lineages of vocal learning birds.
Specialized motor-driven dusp1 expression in the song systems of multiple lineages of vocal learning birds.
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DOI：
10.1371/journal.pone.0042173
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Wada K
中科院分区：
文献类型：
--
作者：
Horita H;Kobayashi M;Liu WC;Oka K;Jarvis ED;Wada K
趋同行为特征的进化机制在很大程度上是未知的。声音学习就是这样一种经过多次进化的特征，对于人类习得口语来说是必要的。在鸟类中，鸣禽、鹦鹉和蜂鸟的声音学习是进化而来的。每一次，专门负责声音学习和产生的类似前脑歌曲核都会进化出来。这一发现引发了这样的假设：声音学习的行为和神经解剖学趋同可能与分子趋同有关。我们之前发现，神经活动诱导的基因双特异性磷酸酶 1 (dusp1) 在非声音回路中上调，特别是在丘脑和端脑的感觉输入神经元中；然而，dusp1 在高级感觉神经元或运动回路中并未上调。在这里，我们表明歌曲运动核是这种模式的一个例外。所有已知的声乐学习鸟类谱系的物种的鸣叫核均表现出由鸣叫引起的运动驱动的 dusp1 表达上调。在非声音运动表现后，前脑的其余部分没有检测到运动驱动的 dusp1 表达。这种模式与通常研究的活动诱导基因egr1的表达形成鲜明对比，egr1显示歌唱诱导的歌曲核中的运动驱动表达，以及非声音运动行为后邻近大脑区域的运动驱动表达。在发声非学习鸟类中，我们在前脑中没有发现可检测到的发声驱动的 dusp1 表达。这些发现表明，声音学习神经系统的独立进化伴随着这些回路中 dusp1 基因的专门运动驱动表达的选择。 dusp1 的这种特殊表达可能会导致声音学习回路中 dusp1 调节的分子级联的差异调节。
Mechanisms for the evolution of convergent behavioral traits are largely unknown. Vocal learning is one such trait that evolved multiple times and is necessary in humans for the acquisition of spoken language. Among birds, vocal learning is evolved in songbirds, parrots, and hummingbirds. Each time similar forebrain song nuclei specialized for vocal learning and production have evolved. This finding led to the hypothesis that the behavioral and neuroanatomical convergences for vocal learning could be associated with molecular convergence. We previously found that the neural activity-induced gene dual specificity phosphatase 1 (dusp1) was up-regulated in non-vocal circuits, specifically in sensory-input neurons of the thalamus and telencephalon; however, dusp1 was not up-regulated in higher order sensory neurons or motor circuits. Here we show that song motor nuclei are an exception to this pattern. The song nuclei of species from all known vocal learning avian lineages showed motor-driven up-regulation of dusp1 expression induced by singing. There was no detectable motor-driven dusp1 expression throughout the rest of the forebrain after non-vocal motor performance. This pattern contrasts with expression of the commonly studied activity-induced gene egr1, which shows motor-driven expression in song nuclei induced by singing, but also motor-driven expression in adjacent brain regions after non-vocal motor behaviors. In the vocal non-learning avian species, we found no detectable vocalizing-driven dusp1 expression in the forebrain. These findings suggest that independent evolutions of neural systems for vocal learning were accompanied by selection for specialized motor-driven expression of the dusp1 gene in those circuits. This specialized expression of dusp1 could potentially lead to differential regulation of dusp1-modulated molecular cascades in vocal learning circuits.
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影响因子：
3.7
作者：
Feenders, Gesa;Liedvogel, Miriam;Rivas, Miriam;Zapka, Manuela;Horita, Haruhito;Hara, Erina;Wada, Kazuhiro;Mouritsen, Henrik;Jarvis, Erich D.
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Jarvis, Erich D.
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通讯作者：
Carninci, Piero
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14.9
作者：
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