Mechanism of Soy Isoflavone Daidzein-Induced Female-Specific Anorectic Effect.
Mechanism of Soy Isoflavone Daidzein-Induced Female-Specific Anorectic Effect.
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DOI：
10.3390/metabo12030252
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发表时间：
2022-03-16
期刊：
影响因子：
4.1
通讯作者：
Kishida T
中科院分区：
文献类型：
--
作者：
Fujitani M;Mizushige T;Adhikari S;Bhattarai K;Kishida T
流行病学研究表明，经常摄入大豆异黄酮能预防绝经后肥胖和其他形式的代谢障碍。雌激素会抑制进食行为。在雌激素缺乏的情况下，大豆异黄酮可以作为雌激素激动剂，而在雌激素重复的条件下，它们可能作为雌激素拮抗剂或无效。采用雄性、去卵巢(OVX)和非去卵巢(OVX)雌性大鼠，研究了不同雌激素条件下饮食中大豆异黄酮对大鼠摄食量的影响，并与雌二醇进行了比较。我们发现，无论是否进行了卵巢摘除，大豆异黄酮都能特异性地减少雌性大鼠的摄食量，而皮下植入雌二醇丸并不会减少完整雌性大鼠的摄食量，但会减少去势雌性和雄性大鼠的摄食量。与这一假设相反，食物摄入量的减少可能不是由大豆异黄酮的雌激素特性引起的。了解大豆异黄酮的厌食作用机制是非常有意义的。在这篇非系统的综述中，我们总结了我们最近研究的厌食活性物质，大豆异黄酮的药代动力学特性，以及大豆异黄酮对调节食欲的中枢和外周信号的修饰，以及通过数据库挖掘确定的精选研究。
Epidemiological studies suggest that regular intake of soy isoflavone exerts a preventive effect on postmenopausal obesity and other forms of dysmetabolism. Estrogens inhibit eating behavior. Soy isoflavones may act as estrogen agonist in estrogen-depleted conditions, whereas they may either act as an estrogen antagonist or be ineffective in estrogen-repleted conditions. We investigated the effects of dietary soy isoflavone on food intake under various estrogen conditions using male, ovariectomized (OVX), and non-OVX female rats, and compared the effects with those of estradiol. We found that soy isoflavones reduced food intake in females specifically, regardless of whether ovariectomy had been performed, whereas subcutaneous implantation of estradiol pellet did not reduce food intake in intact female rats, but did so in OVX female and male rats. Contrary to this hypothesis, the reduction in food intake may not be caused by the estrogenic properties of soy isoflavones. It is of great interest to understand the mechanisms underlying the anorectic effects of soy isoflavones. In this non-systematic review, we summarize our recent studies that have investigated the bioactive substances of anorectic action, pharmacokinetic properties of soy isoflavones, and the modification of central and peripheral signals regulating appetite by soy isoflavones, and selected studies that were identified via database mining.
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影响因子：
4.2
作者：
Goodman-Gruen, D;Kritz-Silverstein, D
通讯作者：
Kritz-Silverstein, D
影响因子：
2.9
作者：
DEBEUN, R;JANSEN, E;VANDEPOLL, NE
通讯作者：
VANDEPOLL, NE
影响因子：
4.1
作者：
Gao, G;Herbert, Z;Caldwell, JD
通讯作者：
Caldwell, JD
影响因子：
5.2
作者：
Bertrand SJ;Hu C;Aksenova MV;Mactutus CF;Booze RM
通讯作者：
Booze RM
影响因子：
2.9
作者：
Chen, JD
通讯作者：
Chen, JD