Plasticity of recurrent l2/3 inhibition and gamma oscillations by whisker experience.
Plasticity of recurrent l2/3 inhibition and gamma oscillations by whisker experience.
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DOI：
10.1016/j.neuron.2013.07.026
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发表时间：
2013-10-02
期刊：
影响因子：
16.2
通讯作者：
Feldman DE
中科院分区：
文献类型：
--
作者：
Shao YR;Isett BR;Miyashita T;Chung J;Pourzia O;Gasperini RJ;Feldman DE
新皮层中的局部递归网络是感觉处理的关键节点，但它们受经验的调节远不如长距离（跨层或跨柱状）投射了解。我们研究了在剥夺诱导的须状图可塑性大鼠体感皮层局部L2/3复发网络，通过表达通道视紫红质-2（ChR 2）在L2/3锥体细胞和测量光诱发的突触电流在离体S1切片。在完整的触须柱，短暂的光脉冲引起反复兴奋和超线性抑制。剥夺列表现出适度减少的兴奋和深刻减少抑制，提供了一个电路的位置，在L2/3在体内观察到的胡须诱发反应的去抑制。较慢的光斜坡引起持续的伽马频率振荡，这几乎被废除在剥夺列。在体内剥夺列的L2/3中的自发LFP振荡中也观察到γ功率的降低。因此，L2/3经常性网络是一个强大的网站，稳态调制的兴奋-抑制平衡和调节γ振荡。
Local recurrent networks in neocortex are critical nodes for sensory processing, but their regulation by experience is much less understood than long-distance (translaminar or cross-columnar) projections. We studied local L2/3 recurrent networks in rat somatosensory cortex during deprivation-induced whisker map plasticity, by expressing channelrhodopsin-2 (ChR2) in L2/3 pyramidal cells and measuring light-evoked synaptic currents in ex vivo S1 slices. In columns with intact whiskers, brief light impulses evoked recurrent excitation and supralinear inhibition. Deprived columns showed modestly reduced excitation and profoundly reduced inhibition, providing a circuit locus for disinhibition of whisker-evoked responses observed in L2/3 in vivo. Slower light ramps elicited sustained gamma frequency oscillations, which were nearly abolished in deprived columns. Reduction in gamma power was also observed in spontaneous LFP oscillations in L2/3 of deprived columns in vivo. Thus, L2/3 recurrent networks are a powerful site for homeostatic modulation of excitation-inhibition balance and regulation of gamma oscillations.
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