Social Interaction With Relapsed Partner Facilitates Cocaine Relapse in Rats.
Social Interaction With Relapsed Partner Facilitates Cocaine Relapse in Rats.
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与复发伴侣的社交互动促进了大鼠可卡因的复发。
DOI：
10.3389/fphar.2021.750397
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发表时间：
2021
影响因子：
5.6
通讯作者：
Xue Y
中科院分区：
文献类型：
--
作者：
Meng S;Yan W;Liu X;Gong Y;Tian S;Wu P;Sun Y;Shi J;Lu L;Yuan K;Xue Y
社会因素极大地促进了吸毒和复发，流行病学研究发现，同龄人群体中的成员相互影响使用毒品。然而，以前的动物模型大多未能纳入社会因素，未能证明社会伴侣对药物成瘾和复发的影响。在本研究中，我们研究了吸毒成瘾大鼠从复吸到寻找可卡因的转移。雄性SD大鼠配对居住，接受可卡因自我给药和条件性位置偏爱(CPP)的训练和戒断。在消退实验后24小时，目标大鼠与可卡因刺激的(复发的)伴侣或陌生人或注射生理盐水(未复发)的伴侣互动30分钟，之后对目标大鼠进行寻药行为测试。我们发现，在大鼠的可卡因自我给药和CPP模型中，与复发伴侣的社交互动增加了寻求毒品的行为，而与未复发的伴侣或复发的陌生人的社交互动对寻求可卡因没有影响。此外，社交对可卡因寻觅的影响可能会持续至少1天。我们的研究结果证实了复发性社会伙伴对大鼠药物复吸的促进作用，并为药物复吸的社会转移提供了一种新的动物模型。
Social factors strongly contribute to drug use and relapse, and epidemiological studies have found that members of peer groups influence each other to use drugs. However, previous animal models mostly failed to incorporate social factors and demonstrate the effects of social partners on drug addiction and relapse. In the present study, we investigated the transfer of relapse to cocaine seeking between drug-addicted partners in rats. Male Sprague–Dawley rats were pair-housed and subjected to training and extinction of cocaine self-administration and conditioned place preference (CPP). 24 h after extinction test, the targeted rats interacted with a cocaine-primed (relapsed) partner or stranger, or saline-injected (unrelapsed) partner for 30 min, after which the targeted rats were tested for drug seeking behavior. We found that social interaction with a relapsed partner increased drug seeking behavior in cocaine self-administration and CPP models in rats, while social interaction with an unrelapsed partner or relapsed stranger had no effect on cocaine seeking. Moreover, the effect of social interaction on cocaine seeking could last for at least 1 day. Our findings demonstrate a facilitation effect of relapsed social partners on drug relapse in rats and provide a novel animal model for social transfer of drug relapse.
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影响因子：
3.4
作者：
Anacker AM;Loftis JM;Kaur S;Ryabinin AE
通讯作者：
Ryabinin AE
影响因子：
3.4
作者：
Miller, CA;Marshall, JF
通讯作者：
Marshall, JF
影响因子：
5.9
作者：
CAUDILL, BD;MARLATT, GA
通讯作者：
MARLATT, GA
影响因子：
1.6
作者：
Peitz GW;Strickland JC;Pitts EG;Foley M;Tonidandel S;Smith MA
通讯作者：
Smith MA
DOI：
10.1007/s10935-005-0014-8
发表时间：
2005-11-01
期刊：
The journal of primary prevention
影响因子：
--
作者：
Bahr, Stephen J;Hoffmann, John P;Yang, Xiaoyan
通讯作者：
Yang, Xiaoyan