Iron as a model nutrient for understanding the nutritional origins of neuropsychiatric disease.
Iron as a model nutrient for understanding the nutritional origins of neuropsychiatric disease.
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DOI：
10.1038/s41390-018-0204-8
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发表时间：
2019-01
影响因子：
3.6
通讯作者：
Georgieff MK
中科院分区：
文献类型：
--
作者：
Barks A;Hall AM;Tran PV;Georgieff MK
产前和产后早期的充足营养在规划早期神经发育中起着关键作用。营养缺乏对神经发育的破坏不仅会导致持久的功能缺陷，而且会增加成年后患神经精神疾病的风险。历史上的饥荒时期，如荷兰的饥饿冬季和中国的饥荒，为发育性营养不良对神经精神结局的长期影响提供了基础性证据。由于神经发育是一个复杂的过程，包括许多营养和脑区特定的关键时期，随后的临床和临床前研究旨在阐明个别宏量和微量营养素缺乏在神经发育和神经精神病理学的具体作用。本综述将讨论发育性铁缺乏症（ID），世界上最常见的微量营养素缺乏症，作为理解早期生命营养在神经发育和神经精神疾病风险中的作用的范例。我们将回顾将ID与神经精神功能障碍联系起来的流行病学数据，以及被认为是这些持久影响的基础的潜在结构、细胞和分子机制。了解驱动持久功能障碍和疾病风险的机制对于制定和实施旨在预防营养缺乏及其长期后遗症的营养政策至关重要。
Adequate nutrition during the pre- and early-postnatal periods plays a critical role in programming early neurodevelopment. Disruption of neurodevelopment by nutritional deficiencies can result not only in lasting functional deficits, but increased risk of neuropsychiatric disease in adulthood. Historical periods of famine such as the Dutch Hunger Winter and the Chinese Famine have provided foundational evidence for the long-term effects of developmental malnutrition on neuropsychiatric outcomes. Because neurodevelopment is a complex process that consists of many nutrient- and brain-region specific critical periods, subsequent clinical and pre-clinical studies have aimed to elucidate the specific roles of individual macro- and micronutrient deficiencies in neurodevelopment and neuropsychiatric pathologies. This review will discuss developmental iron deficiency (ID), the most common micronutrient deficiency worldwide, as a paradigm for understanding the role of early-life nutrition in neurodevelopment and risk of neuropsychiatric disease. We will review the epidemiologic data linking ID to neuropsychiatric dysfunction, as well as the underlying structural, cellular, and molecular mechanisms that are thought to underlie these lasting effects. Understanding the mechanisms driving lasting dysfunction and disease risk is critical for development and implementation of nutritional policies aimed at preventing nutritional deficiencies and their long-term sequelae.
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DOI：
10.1016/j.jpeds.2016.05.013
发表时间：
2016-08
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Cusick SE;Georgieff MK
通讯作者：
Georgieff MK
早期生活节目和神经发育障碍。
影响因子：
10.6
作者：
Bale, Tracy L.;Baram, Tallie Z.;Brown, Alan S.;Goldstein, Jill M.;Insel, Thomas R.;McCarthy, Margaret M.;Nemeroff, Charles B.;Reyes, Teresa M.;Simerly, Richard B.;Susser, Ezra S.;Nestler, Eric J.
通讯作者：
Nestler, Eric J.
影响因子：
64.5
作者：
Chen, Zhongzhou;Zang, Jianye;Zhang, Gongyi
通讯作者：
Zhang, Gongyi
影响因子：
8
作者：
Chang, Suying;Wang, Li;Chen, Chunming
通讯作者：
Chen, Chunming
影响因子：
4.2
作者：
Barks, Amanda;Fretham, Stephanie J. B.;Tran, Phu, V
通讯作者：
Tran, Phu, V