Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety.
Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety.
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DOI：
10.1371/journal.pgen.1009358
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发表时间：
2021-03
期刊：
影响因子：
4.5
通讯作者：
Tullet JMA
中科院分区：
文献类型：
--
作者：
Tataridas-Pallas N;Thompson MA;Howard A;Brown I;Ezcurra M;Wu Z;Silva IG;Saunter CD;Kuerten T;Weinkove D;Blackwell TK;Tullet JMA
饥饿或饱足的感觉是感觉神经系统与其他生理和代谢线索整合的结果。这可以调节食物摄入，保持体内平衡并预防疾病。In C.在线虫中，化学感受神经元感知食物，并通过激素将信息传递给动物的其他部分，以控制与食物相关的行为和生理。在这里，我们确定了这个系统的一个新的组成部分，SKN-1B作为一个中央食物反应节点，最终控制饱腹感和代谢稳态。SKN-1B是哺乳动物NF-E2相关转录因子（Nrfs）的直系同源物，先前已被证明与代谢、呼吸和由饮食限制引起的寿命延长有关。在这里，我们发现SKN-1B在两个下丘脑样ASI神经元中起作用，以感知食物，向生物体传达营养状态，并控制饱腹感和探索行为。这是通过SKN-1B调节内分泌信号通路（IIS和TGF-β）以及促进强大的线粒体网络来实现的。我们的数据表明，哺乳动物Nrf蛋白的食物感应和饱足感的作用。决定何时吃以及吃多少对于保持健康和预防疾病非常重要。它需要在我们的神经、生理和代谢系统之间进行复杂的分子水平的交流。这些信号刺激食物摄入，然后产生饱腹感，使我们停止进食。我们用简单的线虫C.它具有完整的神经系统和可量化的食物相关行为。In C.在线虫中，化学感受神经元感知食物，并通过激素将其传达给动物的其他部分，以控制与食物相关的行为和相关的生理变化。在这里，我们确定了这个系统的一个新的中心节点，C。线虫基因SKN-1B，它在两个感觉神经元中起作用，以感知食物，将食物状态传达给蠕虫的其余部分，并控制饱腹感和探索行为。它通过改变激素信号（胰岛素和转化生长因子-β）和促进强大的线粒体网络来实现这一点。SKN-1B的哺乳动物等效物是NF-E2相关转录因子（Nrfs），其先前与代谢和呼吸有关。我们的数据表明，哺乳动物Nrf蛋白的一个新的食物传感和饱腹感的作用。
The feeling of hunger or satiety results from integration of the sensory nervous system with other physiological and metabolic cues. This regulates food intake, maintains homeostasis and prevents disease. In C. elegans, chemosensory neurons sense food and relay information to the rest of the animal via hormones to control food-related behaviour and physiology. Here we identify a new component of this system, SKN-1B which acts as a central food-responsive node, ultimately controlling satiety and metabolic homeostasis. SKN-1B, an ortholog of mammalian NF-E2 related transcription factors (Nrfs), has previously been implicated with metabolism, respiration and the increased lifespan incurred by dietary restriction. Here we show that SKN-1B acts in two hypothalamus-like ASI neurons to sense food, communicate nutritional status to the organism, and control satiety and exploratory behaviours. This is achieved by SKN-1B modulating endocrine signalling pathways (IIS and TGF-β), and by promoting a robust mitochondrial network. Our data suggest a food-sensing and satiety role for mammalian Nrf proteins. Deciding when and how much to eat is important for maintaining health and preventing disease. It requires an intricate molecular level of communication between our nervous, physiological, and metabolic systems. These signals stimulate food intake, and afterwards the feeling of satiety which makes us stop eating. We have studied these phenomena using the simple nematode worm C. elegans which has a fully mapped nervous system and quantifiable food-related behaviours. In C. elegans, chemosensory neurons sense food and communicate this to the rest of the animal via hormones to control food-related behaviour and associated physiological changes. Here we identify a new central node of this system, the C. elegans gene SKN-1B, which acts in two sensory neurons to sense food, communicate food-status to the rest of the worm, and control satiety and exploratory behaviours. It does this by altering hormonal signalling (Insulin and Transforming Growth Factor-β), and by promoting a strong mitochondrial network. The mammalian equivalents of SKN-1B are the NF-E2 related transcription factors (Nrfs), which have previously been implicated with metabolism and respiration. Our data suggest a new food-sensing and satiety role for mammalian Nrf proteins.
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影响因子：
64.8
作者：
Harris CR;Millman KJ;van der Walt SJ;Gommers R;Virtanen P;Cournapeau D;Wieser E;Taylor J;Berg S;Smith NJ;Kern R;Picus M;Hoyer S;van Kerkwijk MH;Brett M;Haldane A;Del Río JF;Wiebe M;Peterson P;Gérard-Marchant P;Sheppard K;Reddy T;Weckesser W;Abbasi H;Gohlke C;Oliphant TE
通讯作者：
Oliphant TE
影响因子：
8
作者：
Byrne, Joseph J.;Soh, Ming S.;Neumann, Brent
通讯作者：
Neumann, Brent
影响因子：
16.2
作者：
Fujiwara, M;Sengupta, P;McIntire, SL
通讯作者：
McIntire, SL
影响因子：
4.5
作者：
Antebi A
通讯作者：
Antebi A
影响因子：
64.5
作者：
BOWERMAN, B;DRAPER, BW;PRIESS, JR
通讯作者：
PRIESS, JR