Concordance between common dry eye diagnostic tests.
Concordance between common dry eye diagnostic tests.
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DOI：
10.1136/bjo.2007.131722
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发表时间：
2009-01
期刊：
影响因子：
--
通讯作者：
Moore TC
中科院分区：
文献类型：
--
作者：
Moore JE;Graham JE;Goodall EA;Dartt DA;Leccisotti A;McGilligan VE;Moore TC
轻度至中度干眼症的诊断测试结果差异很大，这一点已得到广泛认可。本研究的目的是评估常见干眼症诊断测试之间是否存在一致性。本研究共招募了91例受试者。采用酚红线试验、泪膜破裂时间（TBUT）、生物显微镜检查和结膜杯状细胞印迹细胞学（IC）评价泪膜和眼表。使用McMonnies问卷评估干眼症症状，并评估所有测试之间的统计相关性。该研究队列不包括通过酚红线试验（PRT）确定的严重水缺乏性干眼患者。注意到PRT结果与所有其他试验之间存在统计学显著差异（*P ≤ 0.001）。通过McNemar检验，仅睑板腺病理学、McMonnies问卷、杯状细胞密度降低和TBUT（≤7秒）显示相关性。仅在评估脂质/粘液缺乏的测试（睑板腺评估、杯状细胞密度、TBUT和McMonnies问卷）之间发现相关性。
Large variations in results of diagnostic tests for mild to moderate dry eye are widely recognised. The purpose of this study was to assess if there was concordance between common dry eye diagnostic tests. A total of 91 subjects were recruited to the study. The tear film and ocular surface were evaluated using the phenol red thread test, tear break up time (TBUT), biomicroscopic examination and impression cytological (IC) assessment of conjunctival goblet cells. Dry eye symptoms were assessed using McMonnies questionnaire and statistical correlations between all tests were assessed. This study cohort did not include severe aqueous deficient dry eye patients as determined by the phenol red thread test (PRT). A statistically significant difference was noted between PRT results and all other tests (***P ≤ 0.001). Only meibomian gland pathology, McMonnies questionnaire, reduced goblet cell density and TBUT (≤7 seconds) demonstrated correlation determined by McNemar’s test. A correlation was only found between tests assessing lipid/mucous deficiency (meibomian gland evaluation, goblet cells density, TBUT, and McMonnies questionnaire).
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影响因子：
2.8
作者：
Begley, CG;Caffery, B;Mitchell, GL
通讯作者：
Mitchell, GL
影响因子：
4.1
作者：
Joffre, C.;Souchier, M.;Creuzot-Garcher, C.
通讯作者：
Creuzot-Garcher, C.
影响因子：
1.4
作者：
CHO, P;YAP, M
通讯作者：
YAP, M
影响因子：
1.3
作者：
Anshu;Munshi, MM;Ganar, A
通讯作者：
Ganar, A
影响因子：
4.2
作者：
GOREN, MB;GOREN, SB
通讯作者：
GOREN, SB