Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting.
Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting.
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DOI：
10.1080/19490976.2023.2267180
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发表时间：
2023-12
期刊：
影响因子：
12.2
通讯作者：
中科院分区：
文献类型：
--
作者：
本报告总结了美国退伍军人事务部题为“调节退伍军人与部署有关的慢性病中的微生物组-免疫轴”的实地会议。我们的退伍军人患者群体经历了与服务相关的慢性身心健康问题的高发，如感染、肠易激综合征（IBS）、炎症性肠病（IBD）、各种形式的血液和非血液恶性肿瘤、神经系统疾病、终末期器官衰竭、需要移植和创伤后应激障碍（PTSD）。我们报道了一组科学家的观点，他们专注于科学知识的现状，阐明了上述疾病的机制，新的治疗靶点，以及临床干预新方法的发展。综上所述，我们的研究重点集中在四个研究领域：1)造血细胞和实体器官移植、移植物抗宿主病（GVHD）和移植物排斥反应后微生物组与免疫细胞的相互作用；2)肠道炎症及其在IBD和癌症中的修饰；3)精神和身体健康中的微生物组-神经元-免疫相互作用；4)体内平衡和感染性疾病中的微生物组-微量营养素-免疫相互作用。在这次基于VA领域的会议上，我们提议探索一个多学科、多机构、合作的战略，以启动一个路线图，特别关注与服务相关的慢性病患者之间的宿主微生物-免疫相互作用，以潜在地确定新的和可翻译的治疗靶点。
The present report summarizes the United States Department of Veterans Affairs (VA) field-based meeting titled “Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans.” Our Veteran patient population experiences a high incidence of service-related chronic physical and mental health problems, such as infection, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), various forms of hematological and non-hematological malignancies, neurologic conditions, end-stage organ failure, requiring transplantation, and posttraumatic stress disorder (PTSD). We report the views of a group of scientists who focus on the current state of scientific knowledge elucidating the mechanisms underlying the aforementioned disorders, novel therapeutic targets, and development of new approaches for clinical intervention. In conclusion, we dovetailed on four research areas of interest: 1) microbiome interaction with immune cells after hematopoietic cell and/or solid organ transplantation, graft-versus-host disease (GVHD) and graft rejection, 2) intestinal inflammation and its modification in IBD and cancer, 3) microbiome-neuron-immunity interplay in mental and physical health, and 4) microbiome-micronutrient-immune interactions during homeostasis and infectious diseases. At this VA field-based meeting, we proposed to explore a multi-disciplinary, multi-institutional, collaborative strategy to initiate a roadmap, specifically focusing on host microbiome-immune interactions among those with service-related chronic diseases to potentially identify novel and translatable therapeutic targets.
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影响因子：
3.4
作者：
Brenner LA;Forster JE;Stearns-Yoder KA;Stamper CE;Hoisington AJ;Brostow DP;Mealer M;Wortzel HS;Postolache TT;Lowry CA
通讯作者：
Lowry CA
影响因子：
5.3
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影响因子：
30.3
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Kelly CJ;Zheng L;Campbell EL;Saeedi B;Scholz CC;Bayless AJ;Wilson KE;Glover LE;Kominsky DJ;Magnuson A;Weir TL;Ehrentraut SF;Pickel C;Kuhn KA;Lanis JM;Nguyen V;Taylor CT;Colgan SP
通讯作者：
Colgan SP
影响因子：
1.1
作者：
通讯作者：
--
影响因子：
48
作者：
Langworth-Green, Connor;Patel, Saisha;Duff, Karen
通讯作者：
Duff, Karen