Plasmodium vivax and Plasmodium falciparum at the crossroads of exchange among islands in Vanuatu: implications for malaria elimination strategies.
Plasmodium vivax and Plasmodium falciparum at the crossroads of exchange among islands in Vanuatu: implications for malaria elimination strategies.
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DOI：
10.1371/journal.pone.0119475
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Kaneko A
中科院分区：
文献类型：
--
作者：
Chan CW;Sakihama N;Tachibana S;Idris ZM;Lum JK;Tanabe K;Kaneko A
了解疟原虫的传播和运动对于消除疟疾和预防疟疾复发至关重要。瓦努阿图位于太平洋地区疟疾传播的极限，由于其流行率较低且岛屿环境孤立，因此是消除疟疾计划的理想候选国。我们分析了恶性疟原虫和间日疟原虫种群裂殖子表面蛋白 1 (msp1) 和环子孢子蛋白 (csp) 的变异，以研究瓦努阿图五个岛屿上七个地点的基因流和种群结构模式。同一地点的间日疟原虫的遗传多样性总体高于恶性疟原虫。在间日疟原虫中，高遗传多样性可能是通过地点之间和岛屿之间更大范围的基因流动来维持的。与基因流的不同模式一致，恶性疟原虫（28.81-31.23%）中岛屿间遗传变异的比例显着高于间日疟原虫（-0.53-3.99%）。我们的数据表明，瓦努阿图目前逐岛消除疟疾的战略虽然足以消除恶性疟，但可能需要辅之以更集中的综合措施，以控制间日疟在岛屿之间的移动。
Understanding the transmission and movement of Plasmodium parasites is crucial for malaria elimination and prevention of resurgence. Located at the limit of malaria transmission in the Pacific, Vanuatu is an ideal candidate for elimination programs due to low endemicity and the isolated nature of its island setting. We analyzed the variation in the merozoite surface protein 1 (msp1) and the circumsporozoite protein (csp) of P. falciparum and P. vivax populations to examine the patterns of gene flow and population structures among seven sites on five islands in Vanuatu. Genetic diversity was in general higher in P. vivax than P. falciparum from the same site. In P. vivax, high genetic diversity was likely maintained by greater extent of gene flow among sites and among islands. Consistent with the different patterns of gene flow, the proportion of genetic variance found among islands was substantially higher in P. falciparum (28.81–31.23%) than in P. vivax (-0.53–3.99%). Our data suggest that the current island-by-island malaria elimination strategy in Vanuatu, while adequate for P. falciparum elimination, might need to be complemented with more centrally integrated measures to control P. vivax movement across islands.
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影响因子：
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