The effects of experience of discrimination and acculturation during pregnancy on the developing offspring brain.
The effects of experience of discrimination and acculturation during pregnancy on the developing offspring brain.
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DOI：
10.1038/s41386-023-01765-3
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发表时间：
2024-01
影响因子：
7.6
通讯作者：
Scheinost, Dustin
中科院分区：
文献类型：
--
作者：
Spann, Marisa N.;Alleyne, Kiarra;Holland, Cristin M.;Davids, Antonette;Pierre-Louis, Arline;Bang, Claire;Oyeneye, Victoria;Kiflom, Rebecca;Shea, Eileen;Cheng, Bin;Peterson, Bradley S.;Monk, Catherine;Scheinost, Dustin
人们越来越认识到民族、种族和结构性不平等的经历对健康有害，早期研究表明怀孕母亲的经历可能会影响发育中的胎儿。我们对以西班牙裔为主的怀孕少女样本中的歧视和文化适应经历进行了描述，并评估了它们与新生儿大脑功能连接的关系。我们收集了 165 名女性的文化适应、歧视、孕产妇痛苦（即感知压力、童年创伤和抑郁症状）和社会经济地位的自我报告指标。然后，我们对怀孕期间的文化适应、歧视、感知压力、抑郁症状、创伤和社会经济地位变量进行数据驱动的聚类，以确定歧视或文化适应是否聚类为不同的因素。歧视和文化适应风格加载了感知压力、抑郁症状、创伤和社会经济地位等不同因素，这表明它们与我们样本中的其他因素不同。我们将这些数据驱动的母体表型（歧视和文化适应风格）与婴儿杏仁核静息态功能性 MRI 连接性的测量相关联（n = 38）。母亲的同化报告越高，新生儿的杏仁核和双侧梭状回之间的连接性就越弱。母亲遭受歧视的经历与新生儿的杏仁核和前额皮质之间的连通性较弱以及杏仁核和梭状皮质之间的连通性较强有关。谨慎地说，结果可能表明与成人的独立研究相似，并指出歧视和文化适应的经历可能会影响几代人的杏仁核回路。进一步的前瞻性研究至关重要，需要考虑更多样化的少数群体群体，并对民族、种族和结构因素进行全面评估。
The experience of ethnic, racial, and structural inequalities is increasingly recognized as detrimental to health, and early studies suggest that its experience in pregnant mothers may affect the developing fetus. We characterized discrimination and acculturation experiences in a predominantly Hispanic sample of pregnant adolescent women and assessed their association with functional connectivity in their neonate’s brain. We collected self-report measures of acculturation, discrimination, maternal distress (i.e., perceived stress, childhood trauma, and depressive symptoms), and socioeconomic status in 165 women. Then, we performed a data-driven clustering of acculturation, discrimination, perceived stress, depressive symptoms, trauma, and socioeconomic status variables during pregnancy to determine whether discrimination or acculturation clustered into distinct factors. Discrimination and acculturation styles loaded onto different factors from perceived stress, depressive symptoms, trauma, and socioeconomic status, suggesting that they were distinct from other factors in our sample. We associated these data-driven maternal phenotypes (discrimination and acculturation styles) with measures of resting-state functional MRI connectivity of the infant amygdala (n = 38). Higher maternal report of assimilation was associated with weaker connectivity between their neonate’s amygdala and bilateral fusiform gyrus. Maternal experience of discrimination was associated with weaker connectivity between the amygdala and prefrontal cortex and stronger connectivity between the amygdala and fusiform of their neonate. Cautiously, the results may suggest a similarity to self-contained studies with adults, noting that the experience of discrimination and acculturation may influence amygdala circuitry across generations. Further prospective studies are essential that consider a more diverse population of minoritized individuals and with a comprehensive assessment of ethnic, racial, and structural factors.
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DOI：
10.1016/j.bpsc.2017.11.011
发表时间：
2018-04
期刊：
Biological psychiatry. Cognitive neuroscience and neuroimaging
影响因子：
--
作者：
Clark US;Miller ER;Hegde RR
通讯作者：
Hegde RR
影响因子：
20.8
作者：
Abraído-Lanza AF;Echeverría SE;Flórez KR
通讯作者：
Flórez KR
影响因子：
3.8
作者：
Earnshaw, Valerie A.;Rosenthal, Lisa;Lewis, Jessica B.;Stasko, Emily C.;Tobin, Jonathan N.;Lewis, Tene T.;Reid, Allecia E.;Ickovics, Jeannette R.
通讯作者：
Ickovics, Jeannette R.
影响因子：
2.3
作者：
D'Anna-Hernandez KL;Garcia E;Coussons-Read M;Laudenslager ML;Ross RG
通讯作者：
Ross RG
影响因子：
2.6
作者：
Berboth, Stella;Morawetz, Carmen
通讯作者：
Morawetz, Carmen