Corn oil, but not cocaine, is a more effective reinforcer in obese than in lean Zucker rats.
Corn oil, but not cocaine, is a more effective reinforcer in obese than in lean Zucker rats.
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DOI：
10.1016/j.physbeh.2015.03.002
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发表时间：
2015-05-01
影响因子：
2.9
通讯作者：
Freeman KB
中科院分区：
文献类型：
--
作者：
Townsend EA;Beloate LN;Huskinson SL;Roma PG;Freeman KB
肥胖与大脑对可口食物的异常反应有关，这是一个可能导致非稳态饮食的因素。然而，关于肥胖如何与食物的高可口成分（例如，脂肪），并且如果与肥胖相关的强化过程改变，则推广到非食物减肥。目前的研究比较了脂肪（玉米油）和滥用药物（可卡因）在肥胖和瘦Zucker大鼠中的强化作用。具体来说，肥胖和瘦Zucker大鼠自我管理的玉米油或静脉注射可卡因的行为经济需求程序。对于玉米油，肥胖大鼠的最大需求量较高，需求弹性较低。然而，肥胖大鼠和瘦大鼠对可卡因的需求没有差异。这些结果表明，玉米油形式的脂肪在肥胖Zucker大鼠中是更有效的减肥剂。然而，肥胖大鼠和瘦大鼠对可卡因的需求没有差异，这一事实表明，奖励机制的差异可能是特定于食物的，不一定普遍适用于非食物的。
Obesity is associated with abnormal brain reactivity in response to palatable food consumption, a factor that may contribute to non-homeostatic eating. However, little is known about how obesity interacts with the reinforcing effects of highly palatable constituents of food (e.g., fat), and if altered reinforcement processes associated with obesity generalize to non-food reinforcers. The current study compared the reinforcing effects of a fat (corn oil) and a drug of abuse (cocaine) in obese and lean Zucker rats. Specifically, obese and lean Zucker rats self-administered corn oil or intravenous cocaine in a behavioral economic demand procedure. For corn oil, maximum demand was higher and demand elasticity was lower in the obese rats compared to their lean counterparts. However, there were no differences in demand for cocaine between the obese and lean rats. These results demonstrate that a fat in the form of corn oil is a more effective reinforcer in obese Zucker rats. However, the fact that demand for cocaine was not different between the obese and lean rats suggests that differences in reward mechanisms may be reinforcer-specific and do not necessarily generalize to non-food reinforcers.
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影响因子：
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