Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes Streptomyceschumphonensis SCSIO15079 with Antihyperlipidemic Activities.
Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes Streptomyceschumphonensis SCSIO15079 with Antihyperlipidemic Activities.
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从深海来源的放线菌链霉菌（Streptomyces chumphonensis） SCSIO15079中分离鉴定了6个新的芳香酸（1-6）和3个含有异常肟片段的亮氨酸衍生物（7-9），以及2个已知化合物（10-11）。通过详细的核磁共振、质谱、实验和计算电子圆二色光谱分析确定了1-9的结构，包括绝对构型。化合物1-9的抑菌活性和细胞毒性，以及对HepG2细胞内脂质积累的影响。化合物3和4对10 μM细胞内脂质积累的抑制活性最强，具有潜在的抗高脂血症作用，但其机制有待进一步研究。
Six new aromatic acids (1–6) and three new leucine derivatives containing an unusual oxime moiety (7–9) were isolated and identified from the deep-sea-derived actinomycetes strain Streptomyces chumphonensis SCSIO15079, together with two known compounds (10–11). The structures of 1–9 including absolute configurations were determined by detailed NMR, MS, and experimental and calculated electronic circular dichroism spectroscopic analyses. Compounds 1–9 were evaluated for their antimicrobial and cytotoxicity activities, as well as their effects on intracellular lipid accumulation in HepG2 cells. Compounds 3 and 4, with the most potent inhibitory activity on intracellular lipid accumulation at 10 μM, were revealed with potential antihyperlipidemic effects, although the mechanism needs to be further studied.
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影响因子：
3.2
作者：
Andrade, SE;Saperia, GM;Platt, R
通讯作者：
Platt, R
影响因子：
3.9
作者：
Hosomi, Ryota;Fukunaga, Kenji;Yoshida, Munehiro
通讯作者：
Yoshida, Munehiro
影响因子：
2.6
作者：
Mao, WJ;Li, BF;Xing, HT
通讯作者：
Xing, HT
影响因子：
2
作者：
Lee, Jong-Gyo;Yoo, Ick-Dong;Kim, Won-Gon
通讯作者：
Kim, Won-Gon
影响因子：
5.1
作者：
Luo, Xiaowei;Lin, Xiuping;Liu, Yonghong
通讯作者：
Liu, Yonghong