Towards reference values of pericoronary adipose tissue attenuation: impact of coronary artery and tube voltage in coronary computed tomography angiography.
Towards reference values of pericoronary adipose tissue attenuation: impact of coronary artery and tube voltage in coronary computed tomography angiography.
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DOI：
10.1007/s00330-020-07069-0
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发表时间：
2020-12
影响因子：
5.9
通讯作者：
Vliegenthart R
中科院分区：
文献类型：
--
作者：
Ma R;Ties D;van Assen M;Pelgrim GJ;Sidorenkov G;van Ooijen PMA;van der Harst P;van Dijk R;Vliegenthart R
目的：考虑导管电压的影响，测定冠状动脉CT血管成像(CCTA)无斑块患者左冠状动脉前降支(LAD)、左回旋支(LCX)和右冠状动脉(RCA)的正常冠脉周围脂肪组织平均密度(PCATMA)值。这项回顾性研究包括192名患者(76名男性(39.6%)；中位年龄49岁(范围19-79岁))，他们在2015至2017年间因怀疑冠心病而接受了第三代双源CT的CCTA。我们选择了CCTA上无斑块的患者。在CCTA图像上半自动测量PCATMA，测量长度为10 mm的三支主要冠状动脉近端。组间PCATMA比较采用配对t检验，组间PCATMA比较采用单因素方差分析。总体平均 ± 标准差(SD)为− 90.3 ± 11.1HU。男性PCATMA高于女性：− 88.5 ± 10.5HU对− 91.5 ± 11.3HU(p = 0.001)。LAD、LCX和RCA的PCATMA分别为− 92.4 ± 11.HU、− 88.4 ± 9.9 HU和− 90.2 ± 11.4 HU。两两比较，PCATMA：LAD与Lcx(p <； 0.001)、LAD与RCA(p = 0.009)、Lcx与RCA(p = 0.033)有显著差异。70千伏、80千伏、90千伏、100千伏和120千伏组的PCATMA分别为− 95.6 ± 9.6HU、− 90.2 ± 11.5HU、− 87.3 ± 9.9HU、− 82.7 ± 6.2HU和− 79.3 ± 6.8HU(p <； 0.001)。在CCTA上无斑块的患者，PCATMA随导管电压的变化而变化，但不同冠状动脉(LAD、LCX、RCA)的PCATMA差异不大。需要考虑管电压设置来解释PCATMA值。·在CCTA上无斑块的患者，PCATMA随冠状动脉(LAD、Lcx、RCA)的不同而略有不同。·CCTA的管电压影响PCATMA测量，平均PCATMA随千伏的增加而线性增加。·对于PCATMA的纵向CCTA分析，强烈建议使用等千伏设置。本文的在线版本(10.1007/s00330-020-07069-0)包含向授权用户提供的补充材料。
To determine normal pericoronary adipose tissue mean attenuation (PCATMA) values for left the anterior descending (LAD), left circumflex (LCX), and right coronary artery (RCA) in patients without plaques on coronary CT angiography (cCTA), taking into account tube voltage influence. This retrospective study included 192 patients (76 (39.6%) men; median age 49 years (range, 19–79)) who underwent cCTA with third-generation dual-source CT for the suspicion of CAD between 2015 and 2017. We selected patients without plaque on cCTA. PCATMA was measured semi-automatically on cCTA images in the proximal segment of the three main coronary arteries with 10 mm length. Paired t-testing was used to compare PCATMA between combinations of two coronary arteries within each patient, and one-way ANOVA testing was used to compare PCATMA in different kV groups. The overall mean ± standard deviation (SD) PCATMA was − 90.3 ± 11.1 HU. PCATMA in men was higher than that in women: − 88.5 ± 10.5 HU versus − 91.5 ± 11.3 HU (p = 0.001). PCATMA of LAD, LCX, and RCA was − 92.4 ± 11.6 HU, − 88.4 ± 9.9 HU, and − 90.2 ± 11.4 HU, respectively. Pairwise comparison of the arteries showed significant difference in PCATMA: LAD and LCX (p < 0.001), LAD and RCA (p = 0.009), LCX and RCA (p = 0.033). PCATMA of the 70 kV, 80 kV, 90 kV, 100 kV, and 120 kV groups was − 95.6 ± 9.6 HU, − 90.2 ± 11.5 HU, − 87.3 ± 9.9 HU, − 82.7 ± 6.2 HU, and − 79.3 ± 6.8 HU, respectively (p < 0.001). In patients without plaque on cCTA, PCATMA varied by tube voltage, with minor differences in PCATMA between coronary arteries (LAD, LCX, RCA). PCATMA values need to be interpreted taking into account tube voltage setting. • In patients without plaque on cCTA, PCATMA differs slightly by coronary artery (LAD, LCX, RCA). • Tube voltage of cCTA affects PCATMA measurement, with mean PCATMA increasing linearly with increasing kV. • For longitudinal cCTA analysis of PCATMA , the use of equal kV setting is strongly recommended. The online version of this article (10.1007/s00330-020-07069-0) contains supplementary material, which is available to authorized users.
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DOI：
10.1161/atvbaha.116.307301
发表时间：
2017-05
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Arnold AP;Cassis LA;Eghbali M;Reue K;Sandberg K
通讯作者：
Sandberg K
影响因子：
20.1
作者：
Libby P;Tabas I;Fredman G;Fisher EA
通讯作者：
Fisher EA
影响因子：
5.4
作者：
Goeller, Markus;Achenbach, Stephan;Dey, Damini
通讯作者：
Dey, Damini
影响因子：
5.3
作者：
Fei J;Cook C;Blough E;Santanam N
通讯作者：
Santanam N
影响因子：
3.5
作者：
Mancio, Jennifer;Pinheiro, Marilia;Bettencourt, Nuno
通讯作者：
Bettencourt, Nuno