The concordance of MRI and quantitative autoradiography estimates of the transvascular transfer rate constant of albumin in a rat brain tumor model.
The concordance of MRI and quantitative autoradiography estimates of the transvascular transfer rate constant of albumin in a rat brain tumor model.
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DOI：
10.1002/mrm.22914
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发表时间：
2011-11
影响因子：
3.3
通讯作者：
Fenstermacher, Joseph D.
中科院分区：
文献类型：
--
作者：
Paudyal, Ramesh;Ewing, James R.;Nagaraja, Tavarekere N.;Bagher-Ebadian, Hassan;Knight, Robert A.;Panda, Swayamprava;Lu, Mei;Ledbetter, Karyn;Fenstermacher, Joseph D.
测定了15只大鼠9L脑瘤白蛋白的表观前向转移常数。使用Gd标记的牛血清白蛋白(Gd-BSA)进行MRI研究，然后使用放射性碘标记的血清白蛋白(RISA)进行末端定量放射自显影(QAR)。根据Gd-BSA的血液和组织浓度，Look-Locker MRI估计T1。共同配准QAR和MRI图，选择包括肿瘤及其周围的感兴趣区(ROI)，并使用广义估计方程(GEE)根据每个动物ROI的平均值或逐像素数据比较QAR和MRI图上ROI的两个估计值。感兴趣区分析显示这两个指标之间有中等程度的相关性(r=0.57p=0.026)；逐个像素的GEE分析是一致的(r=0.54p<；0.0001)。QAR与MRI最后时间点(如25分钟)的估计值呈中度相关(ROI r=0.55，p<；0.035；Gee r=0.58，p<；0.0001)。QAR和MRI估计值之间的差异不为零，但MRI 25分钟估计值显著低于QAR估计值。因此，血管通透性的无创性MRI评估可以作为QAR测量的替代方法。
The apparent forward transfer constant, , for albumin was measured in 9L cerebral tumors in 15 rats. An MRI study using gadolinium-labeled bovine serum albumin (Gd-BSA) was followed by terminal quantitative autoradiography (QAR) using radioiodinated serum albumin (RISA). Look-Locker MRI estimates of T1 followed Gd-BSA blood and tissue concentration. QAR and MRI maps of were co-registered, a region of interest (ROI) that included the tumor and its surround was selected, and the two estimates of from the ROI on QAR and MRI maps were compared by either mean per animal ROI or on pixel-by-pixel data using a generalized estimating equation (GEE). An ROI analysis showed a moderate correlation between the two measures (r = 0.57, p = 0.026); pixel-by-pixel GEE analysis concurred (r = 0.54, p < 0.0001). The estimates of QAR with MRI of last time points (e.g., 25 minutes) showed a moderate correlation (ROI r = 0.55, p < 0.035; GEE r = 0.58, p < 0.0001). Differences between the QAR and MRI estimates of did not differ from zero, but the MRI 25 minute estimate was significantly lower than the QAR estimate. Thus, noininvasive MRI estimates of vascular permeability can serve as a surrogate for QAR measures.
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影响因子：
3.3
作者：
Buckley, David L.;Kershaw, Lucy E.;Stanisz, Greg J.
通讯作者：
Stanisz, Greg J.
影响因子：
4.8
作者：
Ferrier, Moira C.;Sarin, Hemant;Butman, John A.
通讯作者：
Butman, John A.
影响因子：
3.3
作者：
Li, X;Rooney, WD;Springer, CS
通讯作者：
Springer, CS
影响因子：
3.3
作者：
Reddy, Sai T.;Berk, David A.;Swartz, Melody A.
通讯作者：
Swartz, Melody A.
影响因子：
3.3
作者：
Bagher-Ebadian, Hassan;Nagaraja, Tavarekere N.;Ewing, James R.
通讯作者：
Ewing, James R.