Investigating discriminative stimulus modulation of opioid seeking after conflict-induced abstinence in sign- and goal-tracking rats.
Investigating discriminative stimulus modulation of opioid seeking after conflict-induced abstinence in sign- and goal-tracking rats.
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DOI：
10.1007/s00213-022-06204-7
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发表时间：
2022-10
影响因子：
3.4
通讯作者：
Calu DJ
中科院分区：
文献类型：
--
作者：
Martin DA;Keefer SE;Calu DJ
区别性刺激（DS）是预测奖励可用性的线索。DS对灭绝有抵抗力，即使在长期禁欲后也会激发药物寻求。以往的研究表明，标志跟踪（ST）和目标跟踪（GT）的差异，巴甫洛夫方法预测不同的线索调制脆弱性可卡因复吸。GT大鼠表现出高度的恢复上下文和DS，而ST大鼠表现出高度的恢复离散的刺激。在这里，我们研究DS是否调制恢复后，电屏障诱导的禁欲和跟踪相关的复发漏洞是否推广到阿片类药物复发。我们研究是否DS调制恢复芬太尼寻求持续存在减少不良后果后，电屏障诱导的禁欲。我们还研究了跟踪差异是否预测了在电屏障诱导的禁欲后寻求芬太尼的DS调制恢复的幅度。我们使用巴甫洛夫杠杆自动成形（PLA）训练，以确定在雄性和雌性Sprague道利大鼠的标志，目标和中间跟踪组。然后，我们在间歇性芬太尼自我给药的DS模型中训练大鼠，并通过施加强度增加的电屏障来消除药物寻求。然后，我们测量了在降低的电势垒强度存在下的DS调制恢复的水平。我们报告说，DS强烈调制芬太尼寻求电屏障诱导的禁欲。芬太尼采集、电屏障诱导的戒断和恢复的DS调制在体征跟踪组和目标跟踪组中相似。歧视性刺激强烈地激发阿片类药物寻求，尽管持续的令人厌恶的后果。巴甫洛夫方法的差异并不能预测在冲突诱导的禁欲后寻求芬太尼的DS调制恢复水平。
Discriminative stimuli (DS) are cues that predict reward availability. DS are resistant to extinction and motivate drug seeking even after long periods of abstinence. Previous studies have demonstrated that sign tracking (ST) and goal tracking (GT) differences in Pavlovian approach predict distinct cue-modulated vulnerabilities to cocaine reinstatement. GT rats show heightened reinstatement to contextual and DS, while ST rats show heightened reinstatement to discrete stimuli. Here we examine whether DS modulate reinstatement after electric barrier induced abstinence and whether tracking-related relapse vulnerabilities generalize to opioid relapse. We examine whether DS-modulated reinstatement to fentanyl seeking persists in the presence of reduced adverse consequences after electric barrier-induced abstinence. We also examine whether tracking differences predict the magnitude of DS-modulated reinstatement of fentanyl seeking after electric barrier-induced abstinence. We used Pavlovian lever autoshaping (PLA) training to determine sign-, goal- and intermediate tracking groups in male and female Sprague Dawley rats. We then trained rats in a DS model of intermittent fentanyl self-administration, and extinguished drug seeking by imposing an electric barrier of increasing intensity. We then measured the level of DS-modulated reinstatement in the presence of a reduced electric barrier intensity. We report that DS strongly modulate fentanyl seeking after electric barrier induced abstinence. DS-modulation of fentanyl acquisition, electric barrier-induced abstinence, and reinstatement was similar for sign- and goal-tracking groups. Discriminative stimuli powerfully motivate opioid seeking, despite continued aversive consequences. Pavlovian approach differences do not predict the level of DS-modulated reinstatement to fentanyl seeking after conflict-induced abstinence.
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DOI：
10.1037/xan0000116
发表时间：
2016-10
影响因子：
1.3
作者：
Patitucci, E.;Nelson, A. J. D.;Dwyer, Dominic M.;Honey, R. C.
通讯作者：
Honey, R. C.
影响因子：
3.4
作者：
Martin-Fardon R;Weiss F
通讯作者：
Weiss F
影响因子：
3.4
作者：
Cooper, Ayelet;Barnea-Ygael, Noam;Zangen, Abraham
通讯作者：
Zangen, Abraham
影响因子：
3.4
作者：
Chang, Stephen E.;Krueger, Lauren D.;Flagel, Shelly B.
通讯作者：
Flagel, Shelly B.
影响因子：
7.6
作者：
Saunders, Benjamin T.;O'Donnell, Elizabeth G.;Robinson, Terry E.
通讯作者：
Robinson, Terry E.