Treadmill Exercise During Cerebral Hypoperfusion Has Only Limited Effects on Cognitive Function in Middle-Aged Subcortical Ischemic Vascular Dementia Mice.
Treadmill Exercise During Cerebral Hypoperfusion Has Only Limited Effects on Cognitive Function in Middle-Aged Subcortical Ischemic Vascular Dementia Mice.
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DOI：
10.3389/fnagi.2021.756537
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发表时间：
2021
影响因子：
4.8
通讯作者：
Arai K
中科院分区：
文献类型：
--
作者：
Ohtomo R;Ishikawa H;Kinoshita K;Chung KK;Hamanaka G;Ohtomo G;Takase H;Wrann CD;Katsuki H;Iwata A;Lok J;Lo EH;Arai K
临床和基础研究表明，运动是一种安全的行为干预措施，可有效改善脑血管疾病（包括皮质下缺血性血管性痴呆（SIVD））的认知功能。然而，尽管 SIVD 是一种与年龄相关的疾病，但大多数基础研究都使用幼龄动物来评估运动的效果。因此，在这项研究中，我们使用中年小鼠来研究跑步机运动如何改变 SIVD 小鼠的认知功能。作为 SIVD 小鼠模型，8 个月大的雄性 C57BL/6J 小鼠通过双侧颈总动脉狭窄诱导长期脑灌注不足。一周后，小鼠被随机分为两组：一组接受为期6周的跑步机运动，一组静坐观察。在对小鼠进行多项行为测试（Y 迷宫、新物体识别和莫里斯水迷宫测试）后，跑步机运动训练被证明只能有效改善 Y 迷宫测试中的认知能力下降。我们之前证明，相同的跑步机运动方案对年轻的低灌注 SIVD 小鼠的所有三项认知测试均有效。因此，我们的研究可能表明，脑灌注不足期间的跑步机运动对老年人群的认知功能影响有限。
Clinical and basic research suggests that exercise is a safe behavioral intervention and is effective for improving cognitive function in cerebrovascular diseases, including subcortical ischemic vascular dementia (SIVD). However, most of the basic research uses young animals to assess the effects of exercise, although SIVD is an age-related disease. In this study, therefore, we used middle-aged mice to examine how treadmill exercise changes the cognitive function of SIVD mice. As a mouse model of SIVD, prolonged cerebral hypoperfusion was induced in 8-month-old male C57BL/6J mice by bilateral common carotid artery stenosis. A week later, the mice were randomly divided into two groups: a group that received 6-week treadmill exercise and a sedentary group for observation. After subjecting the mice to multiple behavioral tests (Y-maze, novel object recognition, and Morris water maze tests), the treadmill exercise training was shown to only be effective in ameliorating cognitive decline in the Y-maze test. We previously demonstrated that the same regimen of treadmill exercise was effective in young hypoperfused-SIVD mice for all three cognitive tests. Therefore, our study may indicate that treadmill exercise during cerebral hypoperfusion has only limited effects on cognitive function in aging populations.
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