Exercise-Mediated Neurogenesis in the Hippocampus via BDNF.
Exercise-Mediated Neurogenesis in the Hippocampus via BDNF.
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DOI：
10.3389/fnins.2018.00052
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发表时间：
2018
影响因子：
4.3
通讯作者：
Nusslock R
中科院分区：
文献类型：
--
作者：
Liu PZ;Nusslock R
众所周知，运动具有许多神经保护和认知益处，特别是与记忆和学习相关的过程。运动介导的海马神经发生是连接它们的一个潜在环节，在运动介导的海马神经发生中，新的神经元产生并整合到海马回路中。本文综述了运动与海马神经发生之间的关系，并确定了一个介导这一过程的关键分子--脑源性神经营养因子（BDNF）。作为神经营养因子家族的一员，BDNF调节神经发生中的许多过程，如分化和存活。虽然运动和BDNF对啮齿类动物海马神经发生的直接作用有更多的了解，但它们对人类认知的相应益处也将被讨论。具体来说，什么是已知的运动介导的海马神经发生将提出，因为它涉及到BDNF，以强调它发挥的关键作用。由于人类大脑的不可及性，对BDNF在人类海马神经发生中的作用知之甚少。因此，将讨论有关人类神经发生的局限性和未来研究领域，包括神经发生和脑源性神经营养因子基因内单核苷酸多态性的间接测量。
Exercise is known to have numerous neuroprotective and cognitive benefits, especially pertaining to memory and learning related processes. One potential link connecting them is exercise-mediated hippocampal neurogenesis, in which new neurons are generated and incorporated into hippocampal circuits. The present review synthesizes the extant literature detailing the relationship between exercise and hippocampal neurogenesis, and identifies a key molecule mediating this process, brain-derived neurotrophic factor (BDNF). As a member of the neurotrophin family, BDNF regulates many of the processes within neurogenesis, such as differentiation and survival. Although much more is known about the direct role that exercise and BDNF have on hippocampal neurogenesis in rodents, their corresponding cognitive benefits in humans will also be discussed. Specifically, what is known about exercise-mediated hippocampal neurogenesis will be presented as it relates to BDNF to highlight the critical role that it plays. Due to the inaccessibility of the human brain, much less is known about the role BDNF plays in human hippocampal neurogenesis. Limitations and future areas of research with regards to human neurogenesis will thus be discussed, including indirect measures of neurogenesis and single nucleotide polymorphisms within the BDNF gene.
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影响因子：
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作者：
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通讯作者：
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通讯作者：
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