Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2).
Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2).
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DOI:
10.1371/journal.pone.0067509
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发表时间:
2013
期刊:
影响因子:
3.7
通讯作者:
Stach JE
中科院分区:
文献类型:
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作者:
Uguru GC;Mondhe M;Goh S;Hesketh A;Bibb MJ;Good L;Stach JE
We demonstrate the first application of synthetic RNA gene silencers in Streptomyces coelicolor A3(2). Peptide nucleic acid and expressed antisense RNA silencers successfully inhibited actinorhodin production. Synthetic RNA silencing was target-specific and is a new tool for gene regulation and metabolic engineering studies in Streptomyces.
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DOI:
10.1023/a:1010254013352
发表时间:
2000-12-01
影响因子:
2.6
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通讯作者:
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