A Fluorinated Ionic Liquid-Based Activatable (19)F MRI Platform Detects Biological Targets.
A Fluorinated Ionic Liquid-Based Activatable (19)F MRI Platform Detects Biological Targets.
复制标题
基于氟化离子液体的可激活 19F MRI 平台检测生物目标
DOI：
10.1016/j.chempr.2020.01.023
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发表时间：
2020-05-14
期刊：
影响因子：
23.5
通讯作者：
Gao J
中科院分区：
文献类型：
--
作者：
Zhu X;Tang X;Lin H;Shi S;Xiong H;Zhou Q;Li A;Wang Q;Chen X;Gao J
19F磁共振成像(19F MRI)由于其可忽略的背景和无限的组织穿透深度，在活体分子成像和临床诊断中具有很好的应用前景。然而，开发具有良好的水溶性和多功能的19F探针用于生物响应和实际应用仍然是一个挑战。在这里，我们报道了氟化离子液体(ILS)作为一种新型的氟化剂，并建立了基于氟化离子液体的可激活19F磁共振成像平台(FILAMP)，该平台依赖于ILS的相变。当暴露在环境刺激下时，涂层聚合物溶解或降解以释放氟化ILS有效载荷，从而迅速增强19F信号。在细胞水平和小鼠体内成功检测到生物靶标(例如，调节失调的pH和基质金属蛋白酶过度表达)，验证了这种“开启”反应，展示了FILAMP作为一种强大的可激活19F探针的潜力，用于诊断和监测生物和病理过程。氟化离子液体(ILS)作为一种新型的氟化试剂，构建了基于氟化离子液体的可激活19F磁共振成像平台(FILAMP)。在生物刺激下，涂层聚合物溶解或降解以释放有效载荷，从而迅速增强19F信号。通过在体外和体内成功检测生物靶标，验证了这种“开启”的反应。总之，FILAMP可以作为一种可激活的19F探针，用于生物和病理过程的诊断和监测。
19F magnetic resonance imaging (19F MRI) is a promising technique for in vivo molecular imaging and clinical diagnosis, benefiting from its negligible background and unlimited tissue penetration depth. However, the development of 19F probes with good water solubility and versatile functions for bioresponsive and practical applications remains a challenge. Here, we report fluorinated ion liquids (ILs) as a new type of fluorine agents and build a fluorinated ionic liquid-based activatable 19F MRI platform (FILAMP), which relies on the phase transition of ILs. Upon exposure to environmental stimulation, coating polymer dissolves or degrades to release the fluorinated ILs payload, which rapidly enhances 19F signal. This “turn-on” response is verified by the successful detection of biological targets (for example, dysregulated pH and MMP overexpression) at the cellular level and in mice, demonstrating the potential of FILAMP as a robust activatable 19F probe for diagnosis and monitoring of biological and pathological processes. Fluorinated ion liquids (ILs) act as a new type of fluorine agents to build a fluorinated ionic liquid-based activatable 19F MRI platform (FILAMP). Upon biological stimulation, the coating polymer dissolves or degrades to release the payload, which rapidly enhances the 19F signals. This “turn-on” response is verified by successful detection of biological targets in vitro and in vivo. In summary, FILAMP can serve as a type of activatable 19F probes for diagnosis and monitoring of biological and pathological processes.
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